绿原酸与氨苄青霉素小儿尿药动力学相互影响  

Interaction of ampicillin and chiorogenic acid in urine pharmacokinetics in children

作　　者：蔡青[1] 袁荣花[1] 孟君[1] 

机构地区：[1]德州市人民医院小儿科,德州253014

出　　处：《中国临床药理学与治疗学》1999年第3期214-217,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的观察双黄连粉针剂中绿原酸与氨苄青霉素在小儿静脉滴注时药物动力学的相互影响。方法临床治疗的呼吸系统感染小儿 ,在静脉滴注双黄连粉针剂(SHLP)60mg·kg-1或(和)氨苄青霉素钠(AMP)150mg·kg-1后采集不同时间段的尿样 ,用高效液相色谱法测定尿中绿原酸(CHA)和AMP浓度。结果两药合用后的24h排出率较单用时有明显下降(P<0.05),CHA和AMP的排出率分别由(51.7±15.6) %和(76.3±20.5) %下降至(42.1±12.2) %和(62.3±19.3) %,t1/2 分别由(3.44±1.14)h和(1.98±0.51)h增加至(4.33±1.38)h和(2.67±0.75)h ,增加明显(P<0.05) ,相应地Cl R 明显下降(P<0.05)。结论SHLP与AMP合用后体内CHA和AMP排出下降。Aim The interaction of ampicillin(AMP) and chiorogenic acid (CHA), a primary component of Shuanghuanglian pulv(SHLP) on urine pharmacokinetics in children was observed. Methods After a single iv-drip dose of 60 mg·kg-1 SHLP or/and 150 mg·kg-1 AMP was given to the children infected in respiratory system, the concentrations of CHA and AMP in the urine collected at varying time points were determined by a high performance liquid chromatography (HPLC). Results Compared with CHA and AMP used alone, there was a decrease (P<0.05) in the discharge rate drugs within 24 h of the two the drugs used in combination from (51.7±15.6) % and (76.3±20.5 )% to (42.1±12.2) %and (62.3±19.3) % for CHA and AMP respectively. The values of t1/2 of CHA and AMP were increased from (3.44±1.14) h and (1.98±0.51) h to (4.33±1.38) h and (2.67±0.75) h(P<0.05).The results led to a decrease in Cl R. Conclusion The discharge of CHA and AMP is decreased when SHLP and AMP are used in combination.

关 键 词：绿原酸 氨苄青霉素 小儿 药动力学 双黄连粉针剂 药物相互作用 

分 类 号：R978.11[医药卫生—药品] R969.1[医药卫生—药学]