地佐辛复合帕瑞昔布钠在小儿扁桃体切除术的超前镇痛作用  

The preemptive analgesia of dezocine in combination with parecoxib in children undergoing tonsillectomy

作　　者：王瑞明[1] 柴小青[1] 陈昆洲[1] 

机构地区：[1]安徽省立医院急救中心麻醉科,合肥230001

出　　处：《安徽医学》2014年第11期1483-1485,共3页Anhui Medical Journal

摘　　要：目的探讨地佐辛复合帕瑞昔布钠在小儿扁桃体切除术超前镇痛的作用。方法 80例择期行扁桃体切除术患儿,随机分为对照组(C组)、地佐辛组(D组)、帕瑞昔布钠组(P组)、地佐辛复合帕瑞昔布钠组(DP组),每组20例,分别于麻醉诱导前5min给予生理盐水、地佐辛0.1 mg/kg、帕瑞昔布钠0.8 mg/kg及地佐辛0.1 mg/kg复合帕瑞昔布钠0.8 mg/kg静脉注射。记录术后患儿拔管后0.5、1、2、4、8、12、24h(T1-7)校正面部疼痛评分(FPS-R评分),观察术后不良反应。结果 D组、P组、DP组术后FPS-R评分均低于C组(P<0.01),DP组术后FPS-R评分低于D组、P组(P<0.01),诱导期间C组、P组患儿呛咳多于D组、DP组(P<0.01),C组患儿术后烦躁多于其他各组(P<0.01)。未见其它不良反应。结论地佐辛、帕瑞昔布钠在小儿扁桃体切除术有超前镇痛作用,二者复合应用效果更佳。Objective To determine the preemptive analgesia of dezocine in combination with parecoxib after tonsillectomy in chil-dren. Methods Eighty children,undergoing selective tonsillectomy were divided into four groups(n=20), control group(C group), dezo-cine group( D group) , parecoxib group ( P group) and dezocine parecoxib group ( DP group) . C group was given normal saline intravenous-ly, D group dezocine 0. 1mg/kg, P group parecoxib 0. 8 mg/kg and DP group ezocine 0. 1mg/kg plus parecoxib 0. 8 mg/kg 5 minutes before induction. The Face Pain Scale-Rvised scales were recorded 0. 5, 1, 2 ,4, 8 ,12, 24 h after extubation. The induction and postoperation complications were recorded. Results The FPS-R scales of D group, P group and DP group were lower than those of C group(P<0. 01). The trend of dysphoria rate was the same as the FPS-R scales(P<0. 01). The FPS-R scales of DP group was lower than D group and P group(P<0. 01). The cough during induction in D and DP group was less than that in the other two groups(P<0. 01). No other complica-tions were seen in the four groups. Conclusion Ezocine and parecoxib have preemptive analgesia after tonsillectomy in children. The pre-emptive analgesia of dezocine in combination with parecoxib is more effective.

关 键 词：地佐辛 帕瑞昔布钠 超前镇痛 儿童 扁桃体切除术 

分 类 号：R726.1[医药卫生—儿科]