雷公藤多甙联合糖皮质激素治疗肾病综合征效果观察  

Efficacy observation of tripter ygium glycosides combined with glucocorticoids for therapy of patients with nephrotic syndrome

作　　者：牛和俊[1] 王笑[2] 陈小元[1] 孟骏[1] 

机构地区：[1]安徽省铜陵市人民医院肾内科,244000 [2]铜陵职业技术学院医学系,安徽铜陵244000

出　　处：《安徽医学》2015年第3期310-312,共3页Anhui Medical Journal

摘　　要：目的研究雷公藤多甙联合糖皮质激素对肾病综合征患者的疗效及安全性。方法将40例肾病综合征患者随机分为研究组和对照组,每组20例,均给予常规治疗。研究组在此基础上,予以雷公藤多甙片联合泼尼松治疗;对照组给予泼尼松治疗。治疗前与治疗后3、6、12个月,观查患者血压、尿常规、24 h尿蛋白、血肌酐、尿素氮、血浆白蛋白、肝功能、血常规、不良反应等情况,并判断疗效。结果治疗3个月后,与对照组比较,研究组Scr、BUN、24 h尿蛋白下降,血浆白蛋白上升,差异有统计学意义(P<0.05)。研究组治疗总有效率为85.00%,显著高于对照组,差异有统计学意义(χ2=4.285,P=0.038)。随访12个月,研究组复发率为11.80%,明显低于对照组,差异有统计学意义(χ2=4.043,P=0.044)。研究组不良反应发生率为10.00%,显著低于对照组,差异有统计学意义(χ2=4.800,P=0.028)。结论雷公藤多甙联合糖皮质激素治疗具有改善肾病综合征患者临床症状,减少复发,副作用少的特点。Objective To study the efficacy and safety of tripterygium glycosides combined with glucocorticoids for the therapy of patients with NS( Nephrotic Syndrome). Methods Forty NS patients were randomly divided into study group and control group with 20 cases in each group. Both groups were given conventional treatment. Study group were treated with tripterygium glycosides combined with glucocorticoids. Control group were treated with prednisone only. 24 hours urine protein,serum creatinine( Scr),urea nitrogen( BUN),and albumin levels were observed before and after 3 months,6 months and 12 months of therapy. Results After 3 months of treatment,compared with control group,Scr,BUN,24-hour urinary protein decreased and serum albumin levels increased significantly in the study group. Total efficiency of the study group( 85. 00%) was significantly higher than that of the control group( 55. 00%)( χ2= 4. 285,P = 0. 038). During 12 months of follow-up,the recurrence rate of the study group( 11. 80%) was significantly lower than that of the control group( 45. 50%)( χ2= 4. 043,P = 0. 044). The incidence of adverse reactions in the study group( 10. 00%) was significantly lower than that of the control group( 40. 00%)( χ2= 4. 800,P = 0. 028). Conclusion Tripterygium glycosides combined with glucocorticoid therapy may improve the clinical symptoms and reduce the recurrence rates with less adverse effect in patients with NS.

关 键 词：肾病综合征 雷公藤多甙 糖皮质激素 

分 类 号：R692[医药卫生—泌尿科学]