Development of self-micellizing solid dispersion system employing amphipathic copolymer for the improvement of dissolution and oral bioavailability of cyclosporine A  

作　　者：Hiroki Suzuki Hideyuki Sato Yoshiki Kojo Takahiro Mizumoto Kayo Yuminoki Naohumi Hashimoto Yoshiki Seto Satomi Onoue 

机构地区：[1]University of Shizuoka,52-1 Yada,Suruga-ku,Shizuoka 422-8526,Japan [2]ILS Inc.,1-2-1 Kubogaoka,Moriya,Ibaraki 302-0104,Japan [3]Setsunan University,45-1 Nagaotoge-cho,Hirakata,Osaka 573-0101,Japan

出　　处：《Asian Journal of Pharmaceutical Sciences》2016年第1期50-51,共2页亚洲药物制剂科学（英文）

摘　　要：The main objective of the present study is to develop a selfmicellizing solid dispersion(SMSD)system of cyclosporine A(CsA)using an amphiphilic copolymer,poly[MPC-co-BMA](pMB)to improve the biopharmaceutical properties of CsA(Fig.1A).Unlike conventional carrier compounds,pMB would perform the bifunctional ability as both polymeric carrier of solid dispersion system and solubilizer derived from a high micellizing property,which could be considered beneficial for the production of highly water soluble formulation of poorly water soluble compound[1].Improvement in the aqueous solubility has been believed to be a key consideration for acquiring potent pharmacological effects of BCS class II drug like CsA.

关 键 词：CYCLOSPORINE A AMPHIPATHIC COPOLYMER Self-micellizing solid dispersion Oral BIOAVAILABILITY 

分 类 号：R943[医药卫生—药剂学]