烷基钴肟辅酶B_(12)模型化合物的电化学性质研究  

ELECTROCHEMICAL PROPERTIES OF ALKYLCOBALOXIME B_(12) MODEL

作　　者：刘君[1] 陈继军[2] 张京君[3] 

机构地区：[1]济宁医学院化学教研室 [2]济宁医学院第二教学医院 [3]济宁医学院附属医院

出　　处：《济宁医学院学报》2002年第2期11-12,共2页Journal of Jining Medical University

摘　　要：目的　研究钴肟类辅酶B12 模型化合物的电化学性质。方法　用循环伏安法研究了钴肟类模型化合物RCo(DMG) 2 ·L(R =n -C3 H7、i-C4 H9、n -C4 H9、n -C5H11、c -C6H11、PhCH2 、Cl,DMG =丁二酮肟 ,L =H2 O)的电化学性质。结果　RCo (DMG) 2 ·L的循环伏安图表明 ,其氧化还原过程伴随两个准可逆氧化还原反应 (1)和 (2 ) ,并伴随Co -C键的断裂 ,且随R的推电子能力增强 ,其氧化还原电位变负。结论　钴肟类化合物是适宜的辅酶B12 模型。Objective Studied on Electrochemical Properties of Alkylcobaloxime B 12 Model.Methods The Electrochemical Properties of Alkylcobaloxime Complexes RCo (DMG)2·L, were R=n-C 3H 7、i-C 4H 9、n-C 4H 9、n-C 5H 11 、c-C 6H 11 、Ph CH 2 and L=H 2O containing the equatorical ligand dimethylglyoxime were studied by cyclic voltammetry. Results Two cathodic-anodic peak system〔(1)and(2)〕 were recorded due to quasi-reversible charge transfer processes and the cleavage of Co-C band can be deduced.It is concluded that values of potentials are decreased with the enhancement of eletron-donoring ability of axial R groups. Conclusion The Alkylcobaloxime Complexes were appropriate to Coenzymes B 12 Models.

关 键 词：电化学性质 辅酶B12 烷基钴肟 Co-C键 循环伏安法 

分 类 号：R313[医药卫生—基础医学]