苯并(a)芘对初次免疫反应和二次免疫反应的影响  

The effect of B(a)P on primary and seconary response in mice

作　　者：薛彬[1] 雷志明[1] 

机构地区：[1]北京医科大学卫生毒理学教研室

出　　处：《职业医学》1991年第2期69-71,127,共3页China Occupational Medicine

基　　金：国家自然科学基金

摘　　要：LACA小鼠经腹腔注射BaP后6天,可使小鼠脾脏及胸腺明显萎缩,但在注射后14天,淋巴器官重量基本恢复到正常水平。200mg/kg BaP对小鼠以SRBC为抗原的初次免疫反应和二次免疫反应均产生明显的抑制作用,100 mg/kg BaP仅对二次免疫反应产生明显的抑制作用。6 days after tfter ip injection of B(a)P to the LACK mice, a decrease of thymus and spleen weight occurred. Hewever, 14 days after the injection, those weights recovered to nermal. Exposure of mice to B(a)P dosing 200mg/ kg suppressed the primary and secondary response to antigen SRBC, while B(a)P dosing 100mg/kg could only show a significant effect on the secondary response. The results indicated that exposure to B(a)P might alter the antibody production in mature B cells.

关 键 词：苯并芘 免疫反应 抗体滴定 

分 类 号：R995[医药卫生—毒理学]