兔血浆中5-单硝酸异山梨醇酯及药动学参数的毛细管气相色谱-电子捕获检测法测定  

Determination of Isosorbide-5-mononitrate in Rabbit Plasma and Its Pharmacokinetic Parameters by CGC-ECD

作　　者：蒋文蕾[1] 夏桂珠[1] 

机构地区：[1]北京大学药学院,北京100083

出　　处：《中国医药工业杂志》2002年第7期344-345,共2页Chinese Journal of Pharmaceuticals

摘　　要：采用毛细管气相色谱 -电子捕获检测法测定兔血浆中的 5 -单硝酸异山梨醇酯及其在兔体内的药物动力学参数。结果显示血浆药物浓度在 5 0～ 15 0 0 ng/ m l范围内线性关系良好 。A capillary GC ECD method for the determination of isosorbide 5 mononitrate in rabbit plasma was established. The accuracy of the method was checked by recoveries. The calibration curve was linear in the range of 50~1500 ng/ml( r =0.9984). The pharmacokinetic study was also reported.

关 键 词：血浆 5-单硝酸异山梨醇酯 药动学 参数 毛细管气相色谱-电子捕获检测法 测定 

分 类 号：R972[医药卫生—药品] R969.1[医药卫生—药学]