肝复健冲剂对大鼠肝纤维化胶原沉积的影响  

INFLUENCE OF GANFUJIAN GRANULE ON COLLAGEN SEDIMENT IN RAT LIVER FIBROSIS

作　　者：钱妍[1] 凌昌全[1] 金岩[1] 

机构地区：[1]中国人民解放军第二军医大学长海医院中医科,上海200433

出　　处：《安徽中医学院学报》2002年第4期36-37,共2页Journal of Anhui Traditional Chinese Medical College

摘　　要：目的 :观察并定量检测肝复健冲剂对二乙基亚硝胺 (DEN )诱导的大鼠肝纤维化的预防作用。方法 :复制DEN诱导的大鼠肝硬化模型 ,同时予肝复健冲剂进行干预 ,采用天狼红 苦味酸染色法及计算机图像分析技术定量检测肝复健冲剂对DEN致大鼠肝纤维化胶原沉积程度的影响。结果 :随模型复制进程 ,大鼠肝内胶原沉积量逐渐增加 ,中药组大鼠肝脏炎性损害及肝硬化程度较对照组大鼠轻 ,肝复健冲剂明显降低肝脏胶原沉积量 (P <0 .0 5 )。结论 :肝复健冲剂可减少肝脏胶原沉积 。Objective: To investigate and quantitatively examine the protective effect of Ganfujian granule on collagen sediment in rat liver fibrosis induced by diethylnitrosamine (DEN). Method: DEN induced live fibrosis model was simulated and Ganfujian granule was used as preventive measure. Influence of Ganfujian granule on collagen sediment in rat liver fibrosis was detected by picric acid sirus red staining method and analyzed with computer image technique. Result: Collagen sediment in rat liver increased gradually. Inflammatory damage and degree of liver cirrhosis were lower in Chinese drug group than those in control group. Collagen sediment in rat liver decreased significantly by Ganfujian granule (P<0.01). Conclusion: Ganfujian granule can retard DEN induced rat liver cirrhosis to certain degree through reducing collagen sediment in rat liver.

关 键 词：肝复健冲剂 大鼠 肝纤维化 胶原沉积 中医药疗法 治疗 

分 类 号：R259.752[医药卫生—中西医结合]