玄参中苯丙素苷对肝细胞损伤保护作用的研究  

The protective activity to hepatocytes of phenylpropanoid glycosides from Scrophularia Ningpoenis

作　　者：孙奎[1] 姜华[2] 

机构地区：[1]第四军医大学吉林军医学院基础部生化教研室,吉林市132013 [2]第二军医大学基础部新药评价中心,上海200433

出　　处：《药学实践杂志》2002年第4期234-235,共2页Journal of Pharmaceutical Practice

摘　　要：目的:研究苯丙素苷对肝细胞损伤的保护作用。方法:通过D—氨基半乳糖造成体外和体内肝细胞损伤,观察苯丙素苷对肝细胞存活率、LDH、ALT和AST的影响。结果:苯丙素苷在体外能提高肝原代培养细胞的存活率,降低LDH水平。在体内能降低肝衰竭大鼠ALT和AST水平。结论:苯丙素苷对D—氨基半乳糖造成肝细胞损伤具有明显的保护作用。OBJECTIVE: To investigate the hepatoprotective activity of phenylpropanoid glycosides METHODS: The hepatocytes injury was induced by D-Gal in vivo and vitro and the cell survival rate、LDH.、ALT、AST were measuremented. RESULTS: phenylpropanoid glycosides can elevated the survival rate of hepatocytes and inhibition the LDH leakage to medium in vitro. It also can suppress the elevation of serum ALT and AST induced by D-Gal in vivo. CONCLUSION:phenylpropanoid glycosides have significant protective effect to hepatocyes injury induced by D-Gal.

关 键 词：玄参 苯丙素苷 肝细胞损伤 保护作用 

分 类 号：R282.71[医药卫生—中药学]