Antidiabetic and antidiarrhoeal potentials of ethanolic extracts of aerial parts of Cynodon dactylon Pers  

作　　者：Md.Saidur Rahman Rasheda Akter Santosh Mazumdar Faridul Islam Nusrat Jahan Mouri Nemai Chandra Nandi Abu Syeed 

机构地区：[1]Mohammad Mahmud Bangladesh Council of Scientific and Industrial Research Laboratories Chittagong

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2015年第8期642-645,共4页亚太热带生物医学杂志（英文版）

基　　金：Supported by Bangladesh Council of Scientific and Industrial Research Laboratories Chittagong,Chittagong-4220,Bangladesh

摘　　要：Objective: To explore the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Cynodon dactylon Pers. aerial parts(EECA) in Wistar rats.Methods: To assess the antidiabetic activity of EECA, oral glucose tolerance test(OGTT) model and alloxan induced diabetic test(AIDT) model were performed. The EECA was used at the doses of 2 g/kg, 1 g/kg and 500 mg/kg body weight in OGTT model and 1.5 g/kg was used for AIDT model. Castor oil-induced diarrhoeal model and gastrointestinal motility test with barium sulphate milk model were performed for evaluating the antidiarrhoeal effects at doses of 1 g/kg, 750 mg/kg respectively.Results: The dose 2 g/kg in OGTT and 1.5 g/kg in AIDT model blood glucose levels decreased significantly(P < 0.01) in Wistar rats that showed antidiabetic effect of EECA. After administration of EECA at the dose of 1 g/kg, the extract showed significant(P < 0.05) antidiarrhoeal activity in castor oil-induced diarrhoeal model. The results were also significant(P < 0.01) in barium sulphate milk model for the same dose by using above mentioned animals.Conclusions: It is concluded that EECA contains both antidiabetic and the antidiarrhoeal properties.Objective: To explore the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Cynodon dactylon Pers. aerial parts(EECA) in Wistar rats.Methods: To assess the antidiabetic activity of EECA, oral glucose tolerance test(OGTT) model and alloxan induced diabetic test(AIDT) model were performed. The EECA was used at the doses of 2 g/kg, 1 g/kg and 500 mg/kg body weight in OGTT model and 1.5 g/kg was used for AIDT model. Castor oil-induced diarrhoeal model and gastrointestinal motility test with barium sulphate milk model were performed for evaluating the antidiarrhoeal effects at doses of 1 g/kg, 750 mg/kg respectively.Results: The dose 2 g/kg in OGTT and 1.5 g/kg in AIDT model blood glucose levels decreased significantly(P &lt; 0.01) in Wistar rats that showed antidiabetic effect of EECA. After administration of EECA at the dose of 1 g/kg, the extract showed significant(P &lt; 0.05) antidiarrhoeal activity in castor oil-induced diarrhoeal model. The results were also significant(P &lt; 0.01) in barium sulphate milk model for the same dose by using above mentioned animals.Conclusions: It is concluded that EECA contains both antidiabetic and the antidiarrhoeal properties.

关 键 词：CYNODON dactylon Ethanolic EXTRACTS ANTIDIABETIC ANTIDIARRHOEAL WISTAR rats 

分 类 号：R285.5[医药卫生—中药学]