The healing effects of herbal preparations from Sambucus ebulus and Urtica dioica in full-thickness wound models  

作　　者：Esmaeil Babaei Mohammad Hossein Asghari Fatemeh Mehdikhani Milad Moloudizargari Emad Ghobadi Seyedeh Rokhsane Hosseini Pouya 

机构地区：[1]Department of Medical Sciences,Sari Branch,Islamic Azad University,P.O.Box 48161-19318,Sari,Iran [2]Department of Pharmacology,Faculty of Medicine,Babol University of Medical Sciences,Babol,Iran [3]Department of Toxicology and Pharmacology,Faculty of Pharmacy,Tehran University of Medical Sciences,Tehran,Iran [4]Faculty of Medicine,Urmia University of Medical Sciences,Urmia,Iran [5]Student Research Committee,Department of Immunology,School of Medicine,Shahid Beheshti University of Medical Sciences,Tehran,Iran [6]Food and Cosmetic Health Research Center,Hormozgan University of Medical Sciences,Bandar Abbas,Iran

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2017年第5期421-427,共7页亚太热带生物医学杂志（英文版）

基　　金：supported by the Faculty of Veterinary Medicine,Urmia University,Urmia,Iran

摘　　要：Objective:To investigate the healing effects of two herbal preparations.Methods:For this purpose,106 wistar rats were divided into 9 groups including a control,eucerine,phenytoin,Urtica dioica(U.dioica)(2%),U.dioica(5%),Sambucus ebulus(S.ebulus)(2%),S.ebulus(5%),combination(2%),and combination(5%)groups.The control group remained untreated,the eucerin and phenytoin groups were considered as the negative and positive controls respectively,and the remaining groups received different concentrations of the ointments.Full thickness wounds were made.The healing process of the wounds was investigated on day 7,14 and 21 of the experiment.Several factors including the number of fibroblasts,new vessel formation(angiogenesis),thickness of the granulomatous tissues(GT),and the overlying epithelium were analyzed.Results:Among the studied groups,all of the treatment groups were significantly different from the control,eucerin,and phenytoin groups in a positive manner with regard to all studied factors(P 0.05).However,the best results were observed with the S.ebulus(2%) and the combination 2% groups(P 0.05).Conclusions:Topical ointments prepared from the extracts of U.dioica and S.ebulus and their combination possess strong wound healing properties.It is postulated that a synergistic effect may exist between the two extracts since the combination 2% showed better results than the sole extracts.Objective:To investigate the healing effects of two herbal preparations.Methods:For this purpose,106 wistar rats were divided into 9 groups including a control,eucerine,phenytoin,Urtica dioica(U.dioica)(2%),U.dioica(5%),Sambucus ebulus(S.ebulus)(2%),S.ebulus(5%),combination(2%),and combination(5%)groups.The control group remained untreated,the eucerin and phenytoin groups were considered as the negative and positive controls respectively,and the remaining groups received different concentrations of the ointments.Full thickness wounds were made.The healing process of the wounds was investigated on day 7,14 and 21 of the experiment.Several factors including the number of fibroblasts,new vessel formation(angiogenesis),thickness of the granulomatous tissues(GT),and the overlying epithelium were analyzed.Results:Among the studied groups,all of the treatment groups were significantly different from the control,eucerin,and phenytoin groups in a positive manner with regard to all studied factors(P 0.05).However,the best results were observed with the S.ebulus(2%) and the combination 2% groups(P 0.05).Conclusions:Topical ointments prepared from the extracts of U.dioica and S.ebulus and their combination possess strong wound healing properties.It is postulated that a synergistic effect may exist between the two extracts since the combination 2% showed better results than the sole extracts.

关 键 词：Wound healing Sambucus ebulus Urtica dioica OINTMENT SKIN Rat 

分 类 号：R285.5[医药卫生—中药学]