大黄对老龄大鼠脑缺血再灌注胃肠损伤保护作用  

Radix et Rhizoma Rhei′s Protective Action on Gastro-intestinal Injury in Senile Rats of Cerebral Ischemia with Reperfusion

作　　者：李建生[1] 赵君玫[1] 郭盛典[1] 李建国[1] 

机构地区：[1]河南中医学院老年医学研究室,河南郑州450008

出　　处：《河南中医》2002年第4期17-19,共3页Henan Traditional Chinese Medicine

基　　金：河南省杰出青年基金 (1999- 0 5 );河南省高校创新人才基金 (2 0 0 0 - 10 )资助

摘　　要：将老龄大鼠分为对照组、模型组、大黄组、尼莫地平组、血栓心脉宁组 ,观察大黄对老龄大鼠全脑缺血再灌注后胃肠病理组织变化及有关指标改变。结果表明 :老龄大鼠脑缺血再灌注胃肠组织损伤明显 ,大黄具有明显保护作用 ,其作用机制与大黄拮抗自由基损伤、调节ATP酶活性和神经肽及单胺类神经递质的变化 ,低肿瘤坏死因子有关。Aged rats were divided into control group, model group, Radix et Rhizoma Rhei group, Nimodipine group and Xueshuan Xinmainin group to observe the histopathological changes of the stomach and intestines and changes of relevant indexes. It displayed an obvious gastro-intestinal tissue injury after reperfusion. And Radix et Rhizoma Rhei has a marked protective action, which is related to its antagonism to free radical injury, and its ability to regulate ATP activity and neuropeptide, as well as changes of monoamine nerve transmitter and hypo-necrosin of tumor.

关 键 词：缺血再灌注 胃肠损伤 保护作用 脑缺血 大黄 药理学 

分 类 号：R259.7[医药卫生—中西医结合] R282.710.5[医药卫生—中医内科学]