松树皮原花素的抗辐射作用  

The antiradiation action of oligomeric procyanidins

作　　者：严玉霞[1] 蒋建伟[1] 林春兰[1] 吴美玉[1] 何文珊[1] 赵迎社[1] 

机构地区：[1]暨南大学医学院生物化学教研室,广东广州510632

出　　处：《中国病理生理杂志》2002年第7期837-839,共3页Chinese Journal of Pathophysiology

基　　金：广东省自然科学基金资助项目 (No .0 0 0 75 4 )

摘　　要：目的和方法 :采用分光光度法及电泳法 ,以紫外线 (ultraviolet,UV)照射所致的红细胞 (RBC)溶血试验、肝匀浆脂质过氧化产物丙二醛 (MDA)水平、受照质粒DNA损伤程度为指标测定松树皮原花素的抗辐射作用。结果 :松树皮原花素能显著抑制受照人RBC溶血作用 ,明显抑制受照小鼠肝匀浆组织脂质过氧化反应 ,并能明显减轻受照质粒PUC18DNA单链的断裂程度。结论 :松树皮原花素能明显减轻辐射引起的自由基损伤 。AIM: To assess the antiradiation effect of oligomeric procyanidins. METHODS: The hemolysis, malondialdehyde(MDA) levels of mouse liver homogenates and the broken degree of DNA single-strain after being irradiated by ultraviolet were examined. RESULTS: Oligomeric procyanidins significantly reduced the hemolysis of erythrocytes induced by ultraviolet irradiation, inhibited the increase in MDA levels of irradiated mouse liver homogenates ( P <0.01), and raised the percentage of supercoil configuration of plasmid PUC 18 irradiated with ultraviolet ( P <0.01). CONCLUSION: Oligomeric procyanidins has an antiradiation effect, the mechanism may be related to its antioxidant action.

关 键 词：抗辐射作用 松树皮原花素 溶血 丙二醛 自由基 紫外线 质粒 松树皮 

分 类 号：R285[医药卫生—中药学]