吸食阿片类毒品对自由基及下丘脑垂体性腺功能的影响及与中医肾虚关系的研究  

Study on opioid addicts' hypothalamus-pituitary-gonad axis, SOD and MDA contents, and the relation with "deficiency of kidney

作　　者：郭瑞林[1] 赵宁侠[1] 任秦有[1] 周建歧 史恒军[1] 侯颖[1] 

机构地区：[1]第四军医大学唐都医院中医科,西安710038 [2]西安市公安局灞桥公安分局戒毒所,西安710038

出　　处：《第三军医大学学报》2002年第7期849-850,共2页Journal of Third Military Medical University

摘　　要：目的　研究吸食阿片类毒品对人体自由基及下丘脑 垂体 性腺功能的影响及与中医肾阳虚相关关系的研究。方法　应用酶标仪及 851光电比色计测定自由基 (SOD、MDA)的含量 ;应用酶免法检测LH、FSH、T的含量。并参考昆明药物依赖性康复中心《阿片类药物戒断症状量表》(OWS) [1 ] 进行戒断肾阳虚损症状积分评定。结果　 1 7例吸毒者外周血检测SOD、MDA明显高于健康人 (P <0 0 1 ) ;LH、FSH、T明显低于健康 (P <0 0 5～ 0 .0 1 )。戒断症状肾阳虚损积分评定 ,1 7例都有典型肾阳虚损症状。结论　吸毒者下丘脑 垂体 性腺轴功能障碍 ,提示 :吸食阿片类毒品可严重损害垂体性腺功能 ,毒品损伤肾经 ,引起肾阳虚损明显 ,认定吸毒人员的中医证型是以肾阳虚损为主 。Objective To study the conditions of opioid addicts on their SOD and MDA contents, hypothalamus pituitary gonad axis, and 'insufficiency of kidney yang'. The idea of Chinese traditional medicine. Methods The contents of SOD and MDA in peripheral blood of 17 drug addicts were determined. The gonad functions were observed by evaluating the concentrations of FSH, LH and T in the venous blood. The scales of their insufficiency of kidney yang were assessed according to the Opioid Withdrawal Scaling produced by the Rehabilitation Center for Drug Dependence of Kunming. Results The contents of SOD and MDA in drug addicts were significantly higher than that in normal people ( P <0 01). The values of LH, FSH and T in the drug addicts were significantly lower than that in normal people ( P <0 001, P <0 01, and P <0 05 respectively). All 17 opioid addicts had obvious symptoms of insufficiency of kidney yang. Conclusion The drug addicts' gonad functions are lower than that in normal people, indicating the dysfunction of hypothalamus pituirary gonad axis. Our findings suggest that most opioid addicts have the insufficiency of kidney yang in the view of Chinese traditional medicine.

关 键 词：阿片类毒品 自由基 下丘脑 垂体 性腺功能 中医肾虚 吸毒者 肾阳虚损 丙二醛 超氧化物歧化酶 

分 类 号：R996[医药卫生—毒理学] R256.5[医药卫生—药学]