N-乙基-α-甲基-3-(三氟甲基)苯乙胺的合成  

Study on the Synthesis of N - ethyl - α - methyl - (Trifluoromethyl) Aminoethylbenzene

作　　者：陈亚萍[1] 徐益明 苏松良 

机构地区：[1]江阴职工大学,江苏江阴214431 [2]四环生物股份有限公司江阴制药厂,214400

出　　处：《化工时刊》2002年第7期33-34,共2页Chemical Industry Times

摘　　要：研究了间三氟甲基苯丙酮、一乙胺、氢气在雷尼镍催化下发生氢胺化反应,反应转化率达到68%,制得N-乙基-α-甲基-3-(三氟甲基)苯乙胺,产品结构经1HNMR和IR分析证明与预期结构相符.The reaction of (3 - trifluoromethyl) - 3 - phenyl - propane - 2 - one and H2, ethylamine under the cata-lysting of Raney was studied, and the yield is about 68%. The product is N - ethyl - α - methyl (trifluoromethyl) aminoethylbenzene, and its chemical elements was confirmed by IR, 1H - NMR.

关 键 词：N-乙基-α-甲基-3-(三氟甲基)苯乙胺 氢胺化 催化 合成 

分 类 号：TQ463[化学工程—制药化工]