HLA-DQB1等位基因与皮肌炎/多发性肌炎相关性研究  

Association of HLA-DQB1 alleles and dermatomyositis/polymyositis

作　　者：韩秀萍[1,2] 翟宁[1] 张庆瑞[3] 李久宏[1] 刘继峰[1] 杜娟[1] 宋芳吉[1] 

机构地区：[1]中国医科大学第一临床学院皮肤科,沈阳110001 [2]中国医科大学第二临床学院皮肤科 [3]中国人民解放军第二O二医院

出　　处：《中华医学遗传学杂志》2002年第4期322-323,共2页Chinese Journal of Medical Genetics

摘　　要：目的　探讨 HL A- DQB1等位基因与皮肌炎 /多发性肌炎 (dermatomyositis/polymyositis,DM/PM)的相关性。方法　采用聚合酶链反应 -序列特异性引物技术 ,检测了 DM/PM患者的 HL A- DQB1等位基因。结果　与 16 0名正常对照比较 ,在 5 2例 DM/PM患者中 HL A- DQB1* 0 4 0 1等位基因频率明显增高 ,且差异有显著性 (RR=3.5 6 ,P=1.79× 10 - 3,Pc<0 .0 5 ) ;HL A- DQB1* 0 30 3的检出频率在 DM/PM患者组中有降低倾向 ,但两组差异无显著性。结论　DM/PM与 HL A- DQB1* 0 4 0 1基因有显著性相关 ,为揭示 DM/PM的发病中免疫遗传学机理所起的作用提供了重要线索和依据。Objective To evaluate further the nature of HLA DQB1 alleles association with dermatomyositis/polymyositis (DM/PM). Methods HLA DQB1 typing of 52 patients with DM/PM were investigated by polymerase chain reaction sequence specific primer method, and the frequencies of HLA DQB1 alleles were compared. Results It was found that the patients with DM/PM had significantly increased frequency of HLA DQB1*0401(RR=3.56, P =1.79×10 -3 , Pc <0.05). Conclusion The results suggest that HLA DQB1*0401 gene contribute to genetic susceptibility to DM/PM.

关 键 词：相关性 皮肌炎 多发性肌炎 人类白细胞抗原-DQB1等位基因 聚合酶链反应-序列特异性引物 

分 类 号：R593.26[医药卫生—内科学]