收缩压,舒张压,脉压在糖尿病并高血压病人肾脏损害中的意义  

SBP,DBP,and Pulse Pressure in Patients of Hypertension,Diabetes Mellitus With Renal Damage

作　　者：王彦[1] 祝之明[1] 谭建聪[1] 祝善俊[1] 赵志刚[1] 周方明[1] 于军[1] 

机构地区：[1]第三军医军大学附属大坪医院,重庆400042

出　　处：《高血压杂志》2002年第4期329-331,共3页Chinese Journal of Hypertension

基　　金：国家自然科学基金资助项目 (3972 5 0 13)

摘　　要：目的　研究 2型糖尿病及高血压病患者脉压 (PP)与尿微量白蛋白 (UmAlb)的关系 ,为早期防治肾脏损害提供临床依据。方法　对 2 71例患者 1,2型糖尿病患者 (DM) 87例、高血压病患者 (EH) 85例和 2型糖尿病合并高血压病患者 (DM +EH) 99例进行血压检测和UmAlb测定。结果　DM组UmAlb与收缩压 (SBP)和舒张压 (DBP)相关性不显著 (P >0 0 5 ) ;而与PP显著正相关 (P <0 0 5 )。EH组UmAlb与SBP和PP呈显著正相关 (P <0 0 5 ) ,而与DBP相关性则不显著 (P >0 0 5 ) ;EH +DM组UmAlb与SBP、DBP、PP均呈显著正相关 (P <0 0 1及 0 0 5 )。UmAlb与PP相关的显著性在EH +DM组中最大 ,r=0 2 82 ,P =0 0 0 2 ,三组患者中反映肾功能的其他指标则与SBP、DBP和PP无相关性。结论　在上述 3种病人中只有PP总是与早期肾损害相关。因此 ,为防止DM和EH患者肾脏损害加重 ,降低PP甚为重要。Objective To study the blood pressure(SBP,DBP,PP) in early stage of renal damage in patients with type 2 diabetes mellitus patients with hypertension(DM+EH). Methods Blood pressure and urinary microalbumin(UmAlb) were measured in 87 cases of type 2 DM,85 cases of EH, 99 cases of type 2 diabetes mellitus with hypertension(DM+EH). Results In type 2 DM patients PP was positively related to UmAlb(P<0.05), while no correlation between SBP and UmAlb. In patients with EH the SBP, PP were both related to UmAlb(P<0.05),with no correlation between DBP and UmAlb. In hypertensive DM(EH+DM) SBP,DBP, and PP were related to UmAlb(P<0.01 and P<0.05 respectively). Conclusion In above three situations(hypertension,2 type DM,hypertension +DM),only PP constantly related to renal function damage. Reduction of PP may be more important to prevent renal damage besides controlling high blood pressure in type 2 DM and EH.

关 键 词：收缩压 舒张压 肾脏损害 2型糖尿病 高血压病 脉压 尿微量白蛋白 

分 类 号：R544.1[医药卫生—心血管疾病]