血管紧张素-1转换酶基因多态性与急性心肌梗死的相关性研究  

Relationship between angiotensin-1 converting enzyme gene polymorphism and acute myocardial infarction

作　　者：赵鹃[1] 曲秀芬[1] 苗润芳[1] 王惠卿[1] 黄永麟[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院心内科,哈尔滨150001

出　　处：《中国急救医学》2002年第8期444-446,共3页Chinese Journal of Critical Care Medicine

基　　金：黑龙江省教育厅科学技术研究项目 (No 10 5 110 5 4)

摘　　要：目的　研究血管紧张素 - 1转换酶 (ACE)基因多态性与急性心肌梗死 (AMI)的相关性。方法　本研究选择了1999～ 2 0 0 0年间在我院住院的 14 0例AMI患者 ,连续地挑选 5 7例非心肌梗死患者作为对照组 ,进行相应的临床观察及实验室检查 ;并从外周血中提取基因组DNA ,利用聚合酶链式反应的方法对ACE基因进行分型。结果　 14 0例AMI患者中ACEDD型百分比明显高于ID、II的患者 (P <0 0 0 0 5 ) ;D等位基因频率显著增高。结论　ACEDD型的AMI患者与Ⅱ、ID型的患者相比 ,有较高的AMI发生率 ;Objective To expolre the polymorphism of the angiotensin-1 converting enzyme(ACE) gene responsible for acute myocardial infarction.Methods In this study,the patients(n=140)with myocardial infarction and control subjects(n=57) who were matched for established risk factors were consecutively selected.ACE genotypes were characterized by PCR method,and all patients were examined clinical and bio-chemical indexes.Results The ACE-DD genotype was more frequent in the patients with acute myocardial infarction than ID or Ⅱ genotypes (P<0 0005),and the D alleles frequency was higher than the I alleles frequency.Conclusion The DD genotype of ACE gene had clear influence on myocardial infarction,and the D alleles substantially increased the incidence of acute myocardial infarction.

关 键 词：相关性研究 血管紧张素-1转换酶 基因多态性 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]