中药814对吸烟加肺炎克雷伯杆菌感染诱发大鼠COPD的防治  

Treatment Effect of Chinese Herb 814 on Rat Chronic Obstructive Pulmonary Disease Induced by Smoke in Combination with Klebsiella Pneumoniae

作　　者：葛晓娜[1] 熊密[1] 郝春荣[1] 

机构地区：[1]华中科技大学同济医学院基础医学院病理学系,武汉430030

出　　处：《华中科技大学学报（医学版）》2002年第4期359-362,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家"九五"科技攻关项目 (No.96 - 90 6 - 0 2 - 16)

摘　　要：应用吸烟加反复肺炎克雷伯杆菌感染法建立大鼠慢性阻塞性肺疾病 (COPD)模型。大鼠分为对照组 (C) ,吸烟加感染组 (SI)和治疗组 (T)。T组于吸烟感染前 3d开始用中药 814灌胃治疗 ,动物分别于第 4、 8、 16周处死。结果表明 ,与 SI组相比 ,第 16周 T组大鼠肺组织细支气管壁增厚程度 ,细支气管狭窄程度以及肺气肿面积均明显减轻(P<0 .0 5 ) ,维多利亚蓝染色显示 ,T组大鼠肺腺泡动脉肌化程度明显小于 SI组 (P<0 .0 5 ) ,与 C组相比无显著差异(P>0 .0 5 )。T组大鼠第 16周 Pa O2 比 SI组增高 (P<0 .0 5 ) ,右心室收缩压 (RVSP)降低 (P<0 .0 5 ) ,两指标接近正常水平。结果提示 ,中药 814对吸烟加肺炎克雷伯杆菌感染诱发的大鼠In order to observe the treatment effect of Chinese herb 814 on chronic obstructive pulmonary disease (COPD) induced by smoke in combination with Klebsiella Pneumoniae, a rat COPD model was established by smoking and repeatedly intranasal infection. Wistar rats were randomly divided into 3 groups: Control group (C), Smoking and infection group (SI) and Treatment group (T). The rats in the T group were administrated with 814 through esophagus three days before smoking and infection. All the animals were killed at the 4th, the 8th and the 16th week respectively. The results were as follows: In comparison with SI group, the thickening of the bronchiole walls, the narrowness of bronchiole lumens, and the area of emphysema were significantly alleviated in the T group. The muscularisation of the intra acinar arteries in the T group was significantly decreased as compared with SI group. Both PaO 2 values and RVSP values in the T group were recovered to normal levels at the 16th week. Our results demonstrated that the Chinese herb 814 has treatment effect on rat COPD induced by smoking in combination with Klebsiella Pneumoniae.

关 键 词：肺炎克雷伯杆菌感染 防治 阻塞性肺疾病 吸烟 细菌感染 中药814 

分 类 号：R259.631[医药卫生—中西医结合]