原发性甲状腺功能减退患者认知功能的研究  

Cognitive function of patients with primary hypothyroidism

作　　者：吴晔[1] 陈芳[1] 俞正炎[2] 崔思松[2] 

机构地区：[1]上海市华东医院内分泌科,200040 [2]上海市老年医学研究所脑功能室

出　　处：《上海医学》2002年第7期408-410,共3页Shanghai Medical Journal

摘　　要：目的　检测原发性甲状腺功能减退患者的认知功能 ,探讨甲状腺激素对脑功能的影响。方法　运用韦氏记忆量表 (WMS)检测 36例甲状腺功能减退患者和 36例健康对照者的脑功能记忆商 (MQ) ,并作相关性分析。结果　甲状腺功能减退组的MQ值较对照组降低 ,差异有显著性 (P <0 .0 1)。甲状腺功能减退患者各亚组间的MQ值比较 ,差异均有显著性 (P <0 .0 5和P <0 .0 1)。结论　甲状腺功能减退时认知功能明显减退 ,当甲状腺功能恢复后 ,认知功能也有所提高。Objective To investigate the effect of thyroid hormone upon cerebral function by measuring the cognitive function in patients with hypothyroidism . Methods To detect, by means of Wechlors Memory Scale (WMS), the memory quotient (MQ) of cerebral function in 36 patients with hypothyroidism and 36 healthy subjects as controls; and to make a correlative comparison between the two groups.Results MQ in hypothyroids was significantly lower than that in the controls ( P <0.01) , and MQs among the sub-groups with hypothyroidism, also have obvious differences ( P <0.05 and P <0.01). Conclusion There occurs an obvious descent in the cognitive function in patients with hypothyroidism. The cognitive function may improve if thyroid function is regained after persistent medical treatment. It should be emphasized so as to avoid delayed treatment. Confusion of patients with hypothyroidism should not be mixed up with Alzheimer′s.

关 键 词：甲状腺功能减退症 认知功能 记忆商 韦氏记忆量表 WMS 

分 类 号：R581.2[医药卫生—内分泌]