中药石膏对烧伤大鼠创面修复的影响及T淋巴细胞,腹腔巨噬细胞功能变化的观察  

Effects of Gypsum on recovery of injury in rats with thermal injury and mechanisms of immune response of T lymphocyte and macrophages

作　　者：胡景新[1] 孟凡会[1] 吴决[1] 息金波[1] 苏畅[1] 范桂华[1] 

机构地区：[1]吉林医学院病理生理教研室

出　　处：《中国病理生理杂志》1991年第3期260-263,共4页Chinese Journal of Pathophysiology

摘　　要：本实验用Wistar大鼠复制烧伤模型,应用中药石膏治疗,观察烧伤及其修复过程中血液中T淋巴细胞及腹腔巨噬细胞功能的变化。结果表明:烧伤大鼠血中T淋巴细胞数和功能明显低于对照组(对照组T淋巴细胞数为52.19±2.82%,烧伤组值为36.00±3.01%,经统计学处理P<0.01);对照组腹腔巨噬细胞吞噬率为75.13±2.50%,而烧伤组值为66.25±1.58%(P<0.01)。应用石膏后大鼠烧伤创面明显恢复,且血中T淋巴细胞数及功能亦明显增高(46.19±3.53%),腹腔巨噬细胞吞噬率亦接近对照组值(73.75±2.99%)。因此,作者推论:中药石膏治疗烧伤的作用可能与机体细胞免疫功能增强有关。This paper studied effects of Gypsum on injury in Wistar rats with thermal injury. It was found that the function of immune response of T lymphocyte in burned rats with fever was decreased obviously (amount of T cell in control groups was 52.19±2.82%, that of burn groups was 36.00±3.01%. P<0.01) Macrophage functions of burned animals decreased too (phagocytosis of macrophages in the control was 75.13±2.50%; burned animals 66.25±1.58%, P<0.01). Effects of Gypsum may inhibit burn fever and improve the injury. It may increase the number of T cell(46.19±3.53%) and function of macrophage(73.75±2.99%) in burned rats. Therefore, the findings indicated that effects of Gypsum on recovery of thermai injury were related apparently to increase of immune function in rats with thermal injury.

关 键 词：烧伤 发热 T细胞 巨噬细胞 石膏 

分 类 号：R644[医药卫生—外科学]