初生期去胸腺雄性大鼠免疫及神经内分泌功能的变化  

Changes of immune and neuroendocrine functions in neonatal thymectomized rats

作　　者：龚守良[1] 刘伟宏[1] 尉军[1] 刘树铮[1] 李柏青[2] 

机构地区：[1]白求恩医科大学放射生物教研室 [2]蚌埠医学院微生物教研室

出　　处：《中国病理生理杂志》1991年第6期588-591,共4页Chinese Journal of Pathophysiology

摘　　要：本研究证实,初生48小时内去胸腺的成年雄性大鼠脾细胞ConA刺激反应性及IL-2活性下降,表明T细胞功能受损。同时,体重、垂体和睾丸重、血清LH和FSH水平、血清和尿睾丸酮含量以及垂体cAMP含量均降低,下丘脑5-HT代谢发生改变。这些结果提示,雄性大鼠去胸腺后可发生下丘脑-垂体-性腺轴功能的改变。The present study has demonstrated a lowered reactivity to Con A stimulation, and also a decreased IL-2 production by splenocytes in adult male rats which were thymectomized within 48 h after birth. Meantime, their body weights, pituitary and testicular weights, serum LH and FSH levels, serum and urine TS contents, and pituitary cAMP contents were all lower than that of the control. The hypothalamic 5-HT metabolism showed that a change of hypothalamic-pituitary-gonad axis might have occured after neonatal thymectomy in male rats.

关 键 词：胸腺 切除术 下丘脑 垂体系统 

分 类 号：R331.4[医药卫生—人体生理学]