甲亢性心肌病中肾素-血管紧张素系统和肌浆网钙泵的变化  

Changes of renin-angiotensin system and sarcoplasmic reticulum Ca^(2+)-ATPase in hyperthyroid cardiomyopathy

作　　者：项阳[1] 黄峻[2] 杨国平[2] 李庆平[2] 李学军[1] 

机构地区：[1]北京大学基础医学院药理学系,北京100083 [2]南京医科大学第一医院心内科

出　　处：《北京大学学报（医学版）》2002年第4期337-341,共5页Journal of Peking University:Health Sciences

摘　　要：目的 :探讨甲亢性心肌病的发病机制。方法 :建立甲亢性心肌病模型 ,观察心肌肥厚指数、心肌细胞直径、心肌胶原容积分数、心肌羟脯氨酸含量、超微结构改变、肌浆网钙泵 (myocardialsarco/endoplasmicCa2 + ATPase,SERCA)活力及心肌血管紧张素Ⅱ 1型受体 (angiotensinⅡreceptortype 1,AT1)mRNA表达的变化 ,以氯沙坦和福辛普利阻断肾素 血管紧张素系统 (renin angiotensinsystem ,RAS)的不同部位 ,观察RAS在甲亢性心肌病模型中的作用。结果 :L 甲状腺激素腹腔给药二周可致左右心室肌明显肥厚 ,胶原组织增生 ,肌浆网钙泵活力下降 ,AT1受体上调 ,氯沙坦和福辛普利可防止甲状腺素诱导的心肌肥厚形成。结论Objective: To explore the etiology of hyperthyroid cardiomyopathy. Methods: We established a hyperthyroid cardiomyopathy model and measured cardiac hypertrophy index,cardiomyocyte diameter,collagen volume fraction ,hydroxyproline content,myocardial pathological changes,the activity of myocardial Sarco/Endoplasmic Ca 2+-ATPase(SERCA) and the level of angiotensin Ⅱreceptor type 1 (AT 1)mRNA expression in cardiac tissue;We determined the role of RAS in the development of thyroxine-incuced cardiac hypertrophy with losartan and fosinopril blocking different position of RAS. Results: In the rats treated by levothyroxine,the left and right ventricules were hypertrophic,collagen content was significantly higher,the activity of myocardial SERCA was clearly lower and an apparently higher level of AT 1 mRNA was seen than those in control rats. Losartan and fosinopril can both prevent the development of cardiac hypertrophy. Conclusion: RAS and SERCA play an important role in the development of hyperthyroid cardiomyopathy.

关 键 词：甲亢性心肌病 肾素-血管紧张素系统 肌浆网钙泵 发病机制 心肌肥厚 

分 类 号：R542.2[医药卫生—心血管疾病]