栝蒌薤白汤对肺纤维化大鼠支气管肺泡灌洗液中层粘连蛋白、Ⅲ型前胶原含量的影响  

Effects of Gualouxiebai Decoction on the Levels of Laminin and Procollagen Ⅲ in the Bronchio-alveolar Lavage Fluid in the Rat with Pulmonary Fibrosis

作　　者：宋建平[1] 楚瑞芬 刘方州[3] 李瑞琴[1] 

机构地区：[1]河南中医学院,河南450008 [2]河南检察官学院医院,河南450003 [3]河南省中医药研究院,河南450004

出　　处：《北京中医药大学学报》2002年第4期29-30,共2页Journal of Beijing University of Traditional Chinese Medicine

基　　金：河南省自然科学基金项目 (No .9840 2 380 0 )

摘　　要：观察栝蒌薤白汤对肺纤维化大鼠支气管肺泡灌洗液 (BALF)中层粘连蛋白 (LN)、Ⅲ型前胶原(PC Ⅲ )含量的影响。用平阳霉素复制大鼠肺纤维化模型后 ,用药组每天灌胃栝蒌薤白汤 ,2 8d后处死 ,观察各组大鼠肺病理组织学改变。结果 :模型组大鼠肺泡炎及纤维化程度、BALF中LN及PC Ⅲ含量均明显高于正常对照组及用药组 (P <0 0 5 )。说明栝蒌薤白汤能明显减轻平阳霉素所致的大鼠肺泡炎及纤维化程度 ,抑制BALF中LN、PC Ⅲ含量的增高。The ffects of Gualouxiebai Decoction (GD) on the Levels of laminin (LN) and procollagen Ⅲ (PC Ⅲ) in the bronchio alveolar lavage fluid (BALF) were observed in the rat with pulmonary fibrosis. The rat model of pulmonary fibrosis was induced by pingyangmycin (bleomycin). The model rats were divided into the model group and drug treating group. The rats in the drug treating group were given GD by gastric perfusion for 28 days, and then executed for the histopathological observation. The results showed that the severity of alveolitis and pulmonary fibrosis was greater, and the levels of LN and PC Ⅲ in BALF were markedly higher in the model group than those in the rats in the drug treating group and normal control group ( P <0 05), which suggests that GD can obviously relieve the severity of alveolitis and pulmonary fibrosis, and inhibit the increase in the levels of LN and PC Ⅲ in BALF.

关 键 词：桥蒌薤白汤 肺纤维化 大鼠 支气管肺泡灌洗液 层粘连蛋白 Ⅲ型前胶原 平阳霉素 

分 类 号：R285.5[医药卫生—中药学] R259.63[医药卫生—中医学]