原发性高血压与肾实质性高血压患者肾上腺髓质素前体N端20肽水平的临床观察  

Elucidation of the changes of proadrenomedullin N-terminal 20 peptide level in hypertension patients with EH and RH

作　　者：张昭馥[1] 石湘芸[1] 费宇行[1] 唐朝枢[2] 

机构地区：[1]海军总医院干三科,100037 [2]北京大学医学部

出　　处：《北京医学》2002年第4期222-224,共3页Beijing Medical Journal

摘　　要：目的　观察原发性高血压 (EH)与肾实质性高血压 (RH)患者肾上腺髓质素前体N端 2 0肽 (PAMP)水平的变化 ,探讨PAMP的降压机制。方法　用放免法测定EH与RH患者的血浆PAMP ,用高压液相 (HPLC)法测定去甲肾上腺素 (NE)、肾上腺素 (E)的水平。结果　EH及RH患者PAMP、NE、E均较正常人明显增高 ,PAMP、MAP与NE、E有明显相关性。结论　EH及RH患者PAMP增高可能是机体维持自稳态的一种保护性代偿机制 ,EH与RH代偿程度有所不同。PAMP降压作用与拮抗NE。Objective To assess the changes of proadrenomedullin N terminal 20 peptide (PAMP) in patients with essential hypetension(EH) and renal hypertension (RH) and explore the mechanism of PAMP in lowing blood pressure.Methods Plasma concentrations of PAMP?nor adrenalin (NE) and adrenalin (E) in EH and RH patients were measured by radio immunoassay(RIA) and HPLC and their associations were calculated.Results Plasma concentrations of PAMP?NE and E in patients with EH and RH were significantly higher than those of normal people.PAMP and the mean arterial pressure(MAP) had significant correlation with NE and E.Conclusions PAMP is a vasodilator peptide.The increase of plasma PAMP may be the self compensatory mechanism by which the body maintains homeostasis.There was a difference in compensatory level between the patients with EH and RH.The action of PAMP in lowing blood pressure is due to the inhibition of NE and E.

关 键 词：肾上腺髓质素前体N端20肽 舒血管肽 原发性高血压 肾实质性高血压 放射免疫法 降压机制 临床观察 

分 类 号：R544.1[医药卫生—心血管疾病]