1-甲基-2-甲氧羰基-4-氨基吡咯盐酸盐的合成  

A New Approach to Methyl 4-Amino-1-methylpyrrole-2-carboxylate Hydrochloride

作　　者：张正波[1] 聂进[1] 

机构地区：[1]华中科技大学化学系,武汉430074

出　　处：《有机化学》2002年第7期519-521,共3页Chinese Journal of Organic Chemistry

摘　　要：以 1 甲基吡咯为原料 ,通过酰化、硝化、酯化、还原、成盐等五步反应 ,合成得到 1 甲基 2 甲氧羰基 4 氨基吡咯盐酸盐 ,总产率 2 0 %左右 .该法具有原料便宜易得、操作简单、产物易于分离提纯等优点 。A new approach to methyl 4-amino-1-methylpyrrole-2-carboxylate is described in this paper. Starting from 1-methylpyrrole, the target compound can be obtained through five steps such as acylation, nitrification, esterification, reduction and salt forming. The total yield it is about 20%. In comparison with other methods, there are some advantages in this method: the materials are cheap and available, and the product can be easily separated and purified. It can be therefore mass-produced which will be in favor of its application to the gene pharmaceutical.

关 键 词：1-甲基-2-甲氧羰基-4-氨基吡咯盐酸盐 合成 1-甲基吡咯 硝化反应 还原反应 总产率 基因药物 中间体 

分 类 号：O626[理学—有机化学]