无花果提取物致突变及抗突变研究  

STUDY ON THE MUTAGENIC AND ANTIMUTAGENIC EFFECTS OF FIG EXTRACT

作　　者：马国建[1] 孟正木 王佾先[1] 张琴芬[1] 薛开先[1] 

机构地区：[1]江苏省肿瘤防治研究所遗传学研究室,江苏南京210009 [2]南京药科大学天然植物化学教研室,江苏南京210009

出　　处：《癌变．畸变．突变》2002年第3期177-180,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家新药研究项目 (97 X 0 )

摘　　要：目的 :研究无花果提取液 (figextract,FE)致突变及抗突变效应。方法 :用体外人淋巴细胞微核测试法 ,研究了FE对丝裂霉素C(MMC)和 射线诱变作用的影响。结果 :FE 0 .0 5～ 0 .4 5 (g/ml)剂量范围内 ,对人淋巴细胞无致突变性 ,但可拮抗MMC和 射线诱发突变和老年人、肿瘤患者自发微核形成。结论Purpose: To study the mutagenic and antimutagenic effects of fig extract (FE). Methods: The in vitro micronucleus test in human lymphocytes was used. The effect of FE on mutagenesis induced by MMC and  ray was studied. Results: Within the dosage of 0.05～0.45 g/ml, FE had no mutagenicity, but inhibited  ray and MMC induced micronucleus formation. FE also inhibited spontaneous micronucleus formation in old donors and tumor patients. Conclusion: FE has an antimutagenic effect.

关 键 词：无花果提取液 微核试验 人淋巴细胞 致突变作用 抗突变作用 

分 类 号：R273.023.1[医药卫生—中西医结合] R285[医药卫生—中医肿瘤科]