萌动激活赤灵芝孢子粉致畸、致突变和抗突变的实验研究  

STUDY OF THE GERMINATION ACTIVATED GANODERMA SPORES ON TERATOGENICITY, MUTAGENICITY AND ANTIMUTAGENICITY

作　　者：邓丽霞[1] 胡斌 陈小君[2] 陈铁江[1] 甘德秀[1] 郑履康[1] 范瑞泉[1] 

机构地区：[1]中山大学公共卫生学院毒理学教研室 [2]中山大学肿瘤研究所,广东广州510089

出　　处：《癌变．畸变．突变》2002年第3期183-185,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的与方法　采用大鼠致畸胎、小鼠骨髓细胞染色体畸变 (CA)分析检测萌动激活赤灵芝孢子粉的致畸胎、致突变和抗突变性。结果 :①灵芝孢子粉小鼠骨髓细胞CA率与阴性对照组比较差别无显著性 (P >0 0 5 )。②灵芝孢子粉对孕鼠体重、胚胎早期发育、胚胎生长发育、以及胎鼠的骨骼发育和内脏器官发育均无不良影响。③灵芝孢子粉各剂量对 4 0mg/kg、5 0mg/kg环磷酰胺 (CP)诱发的小鼠骨髓细胞染色体畸变率有明显的抑制作用 (P <0 .0 5 ,P <0 0 1) ,抑制率分别为 5 6 2 %、34 1%、39 8%和 6 7 8%、5 9 9%、5 2 0 % ,对 5 0mg/kgCP诱发的CA抑制率在 5 2 .0 %以上 ,并有剂量反应关系。结论 :萌动激活赤灵芝孢子粉未见致畸胎和细胞染色体损伤作用 ,对化学物引起的染色体损伤具有一定的拮抗或保护作用。Purpose and Methods: To analyse the effects of the Ganoderma spores on teratogenicity, mutagenicity and anti mutagenicity by the test of teratogenesis in rats and of chromosome aberration(CA) analysis in bone marrow cells of mice. Results: ①The rate of CA in mice induced by the spores had no significant difference as compared with the negative control group (P>0.05).②It did not show the development toxicity in the de \{velopment\} of embryos after treatment of the spores. ③Germination activated ganoderma spores could significantly depress the rate of CA induced by CP(40 mg/kg and 50 mg/kg). The depression rate of CA induced by CP(50 mg/kg) was above 52.0% and showed dose response. Conclusion: Germination activated ganoderma spores had no effects of teratogenicity and chromosome damage, and it possesses the antagonistic or protective effect to the chromosome damage.

关 键 词：萌动激活赤灵芝孢子粉 致畸胎 致突变 抗突变 

分 类 号：R285[医药卫生—中药学]