不同年龄段大骨节病患儿和非患儿硒状态对比分析——兼论尿肌酐和尿羟脯氨酸的变化  

COMPARING ANALYSES OF SELENIUM STATUS IN AGE-REIATED DIFFERENT CHILDREN WITH AND WITHOUT KASHIN-BECK DISEASE

作　　者：吕社民[1] 白偲[1] 张矢远[1] 于志道[1] 熊咏民[1] 莫晓燕[1] 王治伦[2] 丁德修[2] 谭希旺[2] 

机构地区：[1]西安医科大学地方性骨病研究所生化室 [2]西安医科大学地方性骨病研究所临床室

出　　处：《中国地方病防治》1991年第5期257-260,共4页Chinese Journal of Control of Endemic Diseases

摘　　要：本文测定了9～13岁不同年龄段大骨节病患儿和非患儿的身高、体重、血、尿和发硒含量及尿肌酐和羟脯氨酸排泄量。结果表明:不管是患儿,还是非患儿各年龄段硒水平不尽相同,同一年龄的患儿血、尿、发硒均低于非患儿;尿肌酐、羟脯氨酸排泄量患儿和非患儿均随年龄、身高和体重的增加而增高,且呈患儿降低的趋势,与患儿硒状态的改变相一致。最后对硒和大骨节病的关系及对肌肉,软骨代谢的影响进行了讨论。Heights,weights,Selenium contents of whole blood, hair and urine,and urinary creatinine(Cr)and hydroxyproline(Hyp) excretions were determined in age-related different children( 9-13yr)with and without kashin-Beck disease,who all came from Yiao-xian county, an endemic area. Results showed that not only did the patients but also the normal children vary with age,while Se contents of blood,hair and urine in the patients were lower comparied with the same-aged normal children,and that C_r and Hyp excretions were showing a tendency to decrease in the patients contrasted with same-aged normal children although they increased with the rise of age in both groups. Those suggested that the patients exist a lower Se status and that Se significantly effect on the patients muscular and cartilaginous metabolism.

关 键 词：大骨节病 儿童 硒 肌酐 羟脯氨酸 

分 类 号：R684.104[医药卫生—骨科学]