克山病病区粮对大鼠^(54)Mn代谢影响的实验研究  

Experimental study of ^(54)Mn metabolism in rats fed crops from endemic areas of Keshan Disease

作　　者：康保安[1] 吴惠民[1] 徐柏楠 

机构地区：[1]中国地方病防治研究中心克山病研究所

出　　处：《中国地方病学杂志》1991年第5期278-281,共4页Chinese Jouranl of Endemiology

摘　　要：本项研究用克山病病区与非病区粮喂养大鼠14周,做^(54)Mn示踪代谢实验,观察2日和7日时血液、心、肝、脾、肾、肌肉和骨骼对^(54)Mn(MnCl_2)吸收、分布以及从粪、尿中排除情况。结果表明,克山病病区组大鼠各种组织脏器对^(54)Mn 的吸收率普遍低于非病区组,其中以血液、肝、脾、肾、肌肉差异尤为显著,而粪尿中^(54)Mn 排除则明显高于非病区组。证实克山病病区粮可引起机体锰代谢的改变。我们认为克山病病区粮中高锰对发病的作用值得深入探讨。Two groups of Wistar rats were fed crops from endemic and nonendemic areas of Keshan disease respectively for 14 weeks,and then ^(54)Mn tracer metabolismof the animals was studied.The absorption of ^(54)Mn in all specimen of the rats inendemic group was lower than nonendemic group.The elimination of ^(54)Mn infeces and urine of the rats in endemic group was much higher than nonendemicgroup.The fact proved that crops from endemic areas of Keshan disease inducedMn metabolic change.

关 键 词：克山病 锰54 示踪代谢 

分 类 号：R542.302[医药卫生—心血管疾病]