大骨节病区粮水对猴软骨硫代谢的影响  

Effect of grain and water from endemic areas of Kashin-Beck's disease on sulphur metabolism in cartilage of rhesus Monkey

作　　者：周秋丽[1] 常淑芳[1] 白秀起 杨春伟[1] 杨同书[1] 王金木 丁天赞 杨水珍 孙阳 傅书霞 张铁锁 

机构地区：[1]白求恩医大地方病研究所 [2]洛阳地方病防治研究所

出　　处：《中国地方病学杂志》1991年第5期297-300,共4页Chinese Jouranl of Endemiology

摘　　要：用大骨节病区粮水喂养18个月的恒河猴,其软骨基质中的硫酸软骨素(CH·S)含量明显减少,软骨中硫酸软骨素对^(35)S 的摄取能力明显下降,其中以病区水组动物表现尤为明显。与此同时,猴的软骨组织还出现了大骨节病样的病理形态学改变(如关节软骨深层细胞出现大面积坏死等)。上述猴模型出现的生化学改变与以前报告的大白鼠模型实验结果一致。Rhesus Monkeys were fed on grain and water taken from endemic areas of Kashin-Beck disease for 18 months,the results showed that chondroitin sulfatecontent in cartilage matrix arid the incorporation of〔^(35)S〕into cartilage chondroi-tin sulfate decreased significantly,especially in the group fed on endemic water.In addition,Kashin-Beck's disease-like pathological changes were also found inthe cartilage of rhesus Monkey,such as the extensive necrosis of cartilage deeplayer cells in epiphysis.The above mentioned biochemical changes were verysimilar to that of rats reported before.

关 键 词：大骨节病 硫代谢 动物模型 软骨 

分 类 号：R684.102[医药卫生—骨科学]