血府逐瘀汤对心肌成纤维细胞增殖和胶原合成的影响  

Effects of XueFuZhuYu Decoction on Collagen Synthesis and Proliferation of Cardiac Fibroblasts

作　　者：丁志山[1] 高承贤[1] 吉瑞瑞[1] 沃兴德[1] 

机构地区：[1]浙江中医学院分子医学研究所,杭州310053

出　　处：《中药材》2002年第7期481-483,共3页Journal of Chinese Medicinal Materials

基　　金：国国中医药管理局科研基金(编号:97Z026);浙江省自然科学基金(编号:397435)

摘　　要：目的:探讨血府逐瘀汤对心肌成纤维细胞增殖与胶原合成的影响,为血府逐瘀汤防治多种由于心肌成纤维细胞增殖而导致的心脏疾病提供理论依据。方法:采用直接加药和血清药理学方法观察血府逐瘀汤对心肌成纤维细胞增殖与胶原合成的影响。结果:1:80稀释的1 g/ml血府逐瘀汤与含10％血府逐瘀汤鼠血清已经对心肌成纤维细胞增殖有抑制作用,同对照组比较具有显著性差异(P<0.05);1:80稀释的1 g/ml血府逐瘀汤能显著抑制心肌成纤维细胞分泌胶原,达17.9％。结论:血府逐瘀汤不仅能够抑制心肌成纤维细胞增殖,而且具有抑制心肌成纤维细胞分泌胶原的作用,血府逐瘀汤具有抗心肌纤维化的作用。Objective:To study the effects of XueFuZhuYu Decoction (XFZYD) on collagen synthesis and proliferation of cardiac fibrob-lasts and provide academic bases of remedying kinds of heart disease aroused by proliferation of cardiac fibroblasts. Methods: By adding medicine directly and serum pharmacological method. Results: Compared with the control group, 1g/ml XFZYD (dilution 1:80) and 10 percent serum of rat contained XFZYD could significantly inhibit the collagen synthesis and the proliferation of cardiac fibroblasts. Moreover, 1g/ ml XFZYD(dilution 1 :80) could significantly affect collagen secrtion of cardiac fibroblasts (P< 0.05) , up to 17.9% . Conclusion: XFZYD could inhibit both proliferation and collagen secretion of cardiac fibroblasts. It could resist cardiac muscle fibrosis.

关 键 词：血府逐瘀汤 心肌成纤维细胞 胶原 细胞增殖 实验研究 

分 类 号：R285.5[医药卫生—中药学]