益肾清对膜性肾病模型的治疗及其机理研究  

Mechanical Research on Effects of Yishenqing on Membranous Nephropathy

作　　者：宋艳[1] 马建[1] 李长龄[1] 

机构地区：[1]北京大学医学部药学院分子与细胞药理学系,北京100083

出　　处：《中国中药杂志》2002年第7期537-541,共5页China Journal of Chinese Materia Medica

摘　　要：目的 :观察益肾清对家兔膜性肾病的治疗作用及其机理研究。方法 :参考Border法 ,观察益肾清灌胃口服对阳离子化牛血清白蛋白诱导的家兔膜性肾病的治疗作用 ,并了解它对正常小鼠免疫功能、大鼠尿量和血液流变学的影响。结果 :益肾清能明显缓解家兔蛋白尿 ,保护肾功能 ,恢复肾小球的病理改变 ;还具有较强的免疫增强、利尿和活血化瘀功能。结论 :益肾清对治疗家兔膜性肾病具有较好的疗效 ,其作用机制可能与利尿、活血化瘀或免疫增强作用有关。Objective: To investigate the therapeutic effect and mechanism of Yishenqing on rabbit membranous nephropathy. Method: The rabbit membranous nephropathy model was induced by cationic bovine serum albumin, and the immunity of mice together with urine volume and haemorheological property of rats were also estimated. Result: Yishenqing could significantly reduce the urinary protein content, preserve the renal function and pathologically restore the glomeruli. Moreover, its effects also include immunity enhancement, diuretic property and blood stasis amelioration. Conclusion: Yishenqing has good effects on the rabbit membranous nephropathy, which is probably due to the effects of diuretic property, immunity enhancement and blood stasis amelioration.

关 键 词：益肾清 膜性肾病 治疗 机理 研究 阳离子化牛血清白蛋白 

分 类 号：R285.5[医药卫生—中药学] R277.52[医药卫生—中医学]