三种常用染发剂对小鼠骨髓细胞微核的影响  

The effect of hair dye on micronucleus in bone marrow PCE of mice

作　　者：孙美芳[1] 佘素贞[1] 魏凌珍[1] 

机构地区：[1]安徽医科大学公共卫生学院毒理系,合肥230032

出　　处：《安徽医科大学学报》2002年第3期189-190,共2页Acta Universitatis Medicinalis Anhui

基　　金：安徽医科大学校青年科研基金资助 (编号 :5 2 2 0 93 )

摘　　要：目的　以小鼠骨髓PCE微核率为指标 ,观察三种品牌的染发剂是否具有诱变性。方法　昆明种小鼠连续 5d经皮给予受试物 ,剂量分别为 5 0 0 0、2 5 0 0和 12 5 0mg/kg ,另设阴性和阳性对照组 ,观察小鼠骨髓嗜多染红胞微核率。结果　三种染发剂嗜多染红细胞微核率与阴性对照组比较均未见明显增高 (P >0 0 5 )。Objective To study the mutagenesis of three kinds of hair dye using mouse bone marrow PCE micronucleus test. Methods The mice were divided into negative and positive control and three treated groups.Three kinds of hair dye were given for 5 days in doses of 5 000 , 2 500 , 1 250 mg/kg, and micronuclei in bone marrow PCE were analyzed. Results The micronucleus rates did not increase compared with the negative control ( P> 0.05). Conclusion The hair dye does not induce increases of micronucleus rates.

关 键 词：染发剂 小鼠 骨髓细胞 微核 毒性 药物作用 

分 类 号：R168[医药卫生—公共卫生与预防医学] TQ658.34[化学工程—精细化工]