电针对颅脑伤大鼠海马神经元保护作用的可能机制  

Protective effect of electroacupuncture on hippocampal neurons after brain injury in rats

作　　者：刘平[1] 张留宝[1] 苏志达[1] 盛春宁[1] 高魏[1] 骆云[1] 徐斌 

机构地区：[1]第二军医大学南京军医学院组织胚胎学教研室,南京210099 [2]南京中医药大学针灸研究所

出　　处：《第二军医大学学报》2002年第7期782-785,共4页Academic Journal of Second Military Medical University

基　　金：江苏省自然科学基金资助项目 (K9845 )

摘　　要：目的 :探讨电针对颅脑伤大鼠海马神经元保护作用的可能机制。方法 :应用原位杂交、透射电镜及生化检测等方法 ,观察电针治疗前后大鼠海马生长抑素 (SS) - m RNA阳性神经元数与 NO含量的变化。 结果 :颅脑伤大鼠经电针治疗海马 SS-m RNA阳性神经元数减少 ,NO含量下降。 结论 :电针对颅脑伤大鼠海马神经元保护作用可能与 SS- m RNA表达和 NO含量的变化有关。Objective:To study the mechanism of electroacupunture protective effect on hippocampal neurons after brain injury in rats. Methods: SS mRNA in situ hybridization histochemistry, electromicroscopy and biochemical examination for NO were performed to observe the changes in the rat brain after injury. Results: Electroacupuncture method reduced SS mRNA expression and declined content of NO in the hippocampal neurons in damaged area. Conclusion: This result suggests that acupuncture therapy has protective effect on hippocampal neurons after brain injury,the mechanism may reduce expression of SS mRNA and decline content of NO.

关 键 词：颅脑损伤 电针疗法 大鼠 海马 神经元保护作用 

分 类 号：R269.511.5[医药卫生—中西医结合] R246.2[医药卫生—中医外科学]