北京某工厂脊柱关节病的流行病学调查  

Epidemiological study of seronegative spondyloarthropathies in Beijing area

作　　者：陈韧 杜丽川[2] 林秋强 陈肃标[3] 林玲[3] 许敬才 谢素和[3] 

机构地区：[1]广东澄海市人民医院,515800 [2]北京朝阳医院内科 [3]汕头大学医学院

出　　处：《中国基层医药》2002年第7期593-594,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　了解北京地区血清阴性脊柱关节病 (SpA)的流行情况。 方法　用修订的中国 国际抗风湿联盟风湿病调查表 ,对北京市区某工厂职工及 16岁以上家属 1982名挨户逐人询问 ,阳性者进行体检 ,疑似者行类风湿因子 (RF)、HLA B2 7和X线检查。结果　脊柱关节病患病率 16 1‰ ,其中强直性脊柱炎 (AS)3 0‰ ,未分化脊柱关节病 (uSpA) 12 1‰ ,除 2例银屑病性关节炎外 ,未发现其他SpA。uSpA主要症状为炎症性腰痛 (83 3% )、非对称性下肢大关节痛 (6 2 5 % ) ,RF均 (- ) ,2 5 0 %HLA B2 7(+) ,男女比例 1 2∶1。结论　SpA在北京地区常见 ,其主要构成为AS和uSpA。Objective To evaluate the prevalence of spondyloarthropathies in Beijing area.Methods Samples of 1982 workers and their adults relatives of a factory in Beijing were studied.The revised questionnaire of LIAR China study was administered in a house to house survey.Physical examination was done in all who gave positive answers.For those who gave positive response to certain set of questions,rheumatoid factor(RF),HLA B 27 ,and radiographs of pelvis and lumbar spine were done.The X ray films were read blindly and separately by 2 radiologists.The 1984 Revised New York criteria for AS,and Amor Criteria for SpA were used.Results The prevalence of SpA was 16.1‰(32/1982),in which the prevalence of AS was 3.0‰(6/1982),and uSpA was 12.1‰(24/1982),excepted 2 cases of psoriatic arthritis,no other subset of SpA was found.Sex ratio of male to female was 5∶1 in AS and 1.2∶1 in uSpA.Of the uSpA cases,the main clinical symptoms were inflammatory low back pain(83.3%),asymmetric oligoarthritis in the low limbs(62.5%).RF was negative in all patients.25.0%(6/24) cases were HLA B 27 positive.Conclusion SpA is common in Beijing area,of which,the major subset was AS and uSpA.Clinical follow up of uSpA is helpful in the early diagnosis of AS and the other SpA.

关 键 词：血清阴性脊柱关节病 流行病学调查 患病率 风湿病 北京 

分 类 号：R181.3[医药卫生—流行病学]