Kindlin-2 expression in adult tissues correlates with their embryonic origins  

作　　者：ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan 

机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research,Ministry of Education,Peking University Health Science Center [2]State Key Laboratory of Natural and Biomimetic Drugs,Peking University Health Science Center [3]Laboratory of Molecular Cell Biology and Tumor Biology,department of anatomy,histology and embryology [4]Department of Thoracic Surgery,Sino-Japan Friendship Hospital [5]Department of Immunology,Third Military Medical University

出　　处：《Science China(Life Sciences)》2014年第7期690-697,共8页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (81301802,81230051,30830048,81321003,31170711);Ministry of Science and Technology of China (2013CB910501,2010CB912203,2010CB529402);Program of Introducing Talents of Discipline to Universities of Ministry of Education;Beijing Natural Science Foundation (7120002);Peking University (BMU20120314,BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau

摘　　要：Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development.Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development.

关 键 词：Kindlin-2 germinal layers migration EMBRYO 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]