异烟肼致罕见血液系统异常3例及文献分析  

3 Cases of Infrequent Hematologic Disorder Induced by Isoniazid and Literature Analysis

作　　者：刘丽娟[1] 周学琴[1] 黄华[2] 

机构地区：[1]北京大学深圳医院,广东深圳518036 [2]深圳市第三人民医院,广东深圳518112

出　　处：《中国药房》2014年第28期2641-2643,共3页China Pharmacy

摘　　要：目的:为判定异烟肼所致血液系统异常提供参考。方法:对3例异烟肼致罕见血液系统异常病例的相关情况进行描述,并进行文献回顾性分析。结果:异烟肼致罕见血液系统异常包括铁粒幼细胞性贫血、血小板减少性紫癜、急性再生障碍性贫血等,与δ氨基酮戊酸盐合成酶2抑制作用、过敏反应等因素有关。结论:虽然异烟肼致不良反应多以过敏反应、肝损害为主,但也必须警惕其血液系统不良反应,在用药前后需对患者进行监测,发现异常及时给予处理。OBJECTIVE：To provide reference for hematologic disorder induced by isoniazid. METHODS：3 cases of infrequent hematologic disorder induced by isoniazid were interpreted,and related literatures were analyzed retrospectively. RESULTS：The infrequent hematologic disorder induced by isoniazid included sideroblastic anemia,essential thrombopenia and acute aplastic anemia,etc.,which were associated with inhibitory effect of δ aminolevulinate synthase 2 and allergic reaction,etc. CONCLUSIONS：ADR induced by isoniazid mainly are anaphylactic reaction and hepatic lesion. Great importance should be attached to ADR of hematologic system and ADR monitoring before and after the drug use so as to dispose timely.

关 键 词：异烟肼 罕见 血液系统异常 文献回顾 

分 类 号：R978.3[医药卫生—药品]