噻托溴铵和盐酸氨溴索在慢性阻塞性肺疾病中的应用观察  

Clinical application of tiotropium bromide combined with ambroxol hydrochloride in treating chronic obstructive pulmonary disease at remission

作　　者：刘康宁[1] 李群峰[1] 吴靖升 

机构地区：[1]江门市新会中医院,广东江门529100

出　　处：《基层医学论坛》2014年第19期2460-2461,共2页The Medical Forum

摘　　要：目的探讨吸入噻托溴铵联合口服盐酸氨溴索对慢性阻塞性肺疾病缓解期的治疗作用。方法将38例慢性阻塞性肺疾病缓解期患者按随机数字表法分为对照组和治疗组,每组各19例。对照组在缓解期常规嘱规范作息、适度锻炼,合理营养,根据天气加减衣物,避免着凉,如果出现急性加重,予抗感染、对症等综合治疗;治疗组在对照组的基础上吸入噻托溴铵和口服盐酸氨溴索。2组疗程均为6个月,观察治疗期间2组患者每天咳痰次数、急性发作次数、慢性阻塞性肺疾病评分(CAT)。结果治疗期间治疗组每日咳痰次数明显少于对照组,2组比较有显著性差异(P<0.01);治疗组急性发作总次数明显少于对照组,2组比较有显著性差异(P<0.05);治疗组CAT评分明显少于对照组,2组比较有显著性差异(P<0.05)。结论慢性阻塞性肺疾病患者在缓解期吸入噻托溴铵和口服盐酸氨溴索,能有效地减少咳痰和急性发作次数,改善患者的生活质量。Objective To observe the effect of tiotropium bromide combined with ambroxol Hydrochloride oral liquid on chronic obstructive pulmonary disease（COPD）at remission. Methods 38 patients with COPD at remission were randomly divided into treatment group and control group. The control group was given with conventional treatment,and anti-infection and symptomatic treatment when acute attacking,while the treatment group was treated with inhaled tiotropium bromide and ambroxol Hydrochloride oral liquid base on the control group. Both groups were treated and observed for 6 months. Times of expectoration and acute attack of COPD were observed,and scores of COPD Assessment Test（CAT）were noted everyday during therapy. Results Compared with the control group,the total times and means of expectoration in treatment group were much less,with significant statistical difference（P〈0.01）; the cases,times and means of acute attack of COPD were obviously less than those in control group,with very significant statistical difference（P〈0.05）; the total scores and means of CAT in treatment group were much lower,with significant statistical difference（P〈0.05）. Conclusion With long-term treatment,inhaled tiotropium bromide combined with ambroxol hydrochloride oral liquid can effectively decrease the times of expectoration and acute attack in patients with COPD at remission,and improve their qualities of life.

关 键 词：慢性阻塞性肺疾病 缓解期 噻托溴铵 盐酸氨溴索 

分 类 号：R563.9[医药卫生—呼吸系统]