灵芪胶囊对H22荷瘤小鼠基质金属蛋白酶-9表达的影响  

Influence of Lingqi capsule on Matrix Metalloproteinases-9 of H22 Tumor-bearing Mice

作　　者：王国胜[1] 李环[2] 霍建波 张鲁权 苏云明[4] 

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150000 [2]深圳大学,广东深圳518000 [3]哈尔滨市呼兰区第二人民医院,黑龙江哈尔滨150000 [4]黑龙江中医药大学,黑龙江哈尔滨150000

出　　处：《中医学报》2014年第7期945-946,共2页Acta Chinese Medicine

基　　金：黑龙江省自然科学基金项目(编号:D201074)

摘　　要：目的:探讨灵芪胶囊抗肿瘤的作用机制。方法:采用免疫组织化学方法检测灵芪胶囊(LQC)对荷瘤小鼠基质金属蛋白酶-9(MMP-9)的影响。结果:MMP-9在模型组中呈明显阳性表达,灵芪胶囊高剂量组、中剂量组、低剂量组与模型组比较,MMP-9的表达较低,差异均具有统计学意义(P<0.05)。灵芪胶囊高剂量组与阳性对照组及复合用药组比较,无明显差异(P>0.05)。结论:灵芪胶囊能够明显抑制H22荷瘤小鼠肿瘤组织中MMP-9的表达,从而抑制肿瘤的生长和转移。Objective： To investigate the antineoplastic action mechanism of Lingqi capsule. Methods： Use immunohistochemical method to investigate the effect of Lingqi capsule on matrix metalloproteinases-9 of H22 tumor-bearing mice. Results： Expression of MMP-9 in model group was obviously positive expression. Compared the Lingqi capsule high dose group,medium dose group and low dose group with model group,MMP-9 expression was lower. The difference had statistical significance（P〈0. 05）. Conclusion： Lingqi capsule can inhibit MMP-9 expression of H22 tumor-bearing mice so that inhibits tumor growth and metastasis.

关 键 词：灵芪胶囊 H22荷瘤小鼠 基质金属蛋白酶-9 免疫组织化学 

分 类 号：R273[医药卫生—中西医结合]