丙泊酚复合布托啡咯在胃镜检查中的应用效果观察  

Efficiency of butorphanol combined with propofol in gastroscopic examination

作　　者：刘涛涛[1] 李勇[1] 杜莹莹[1] 武天珍 张伟[1] 方春霞[1] 

机构地区：[1]四川省广元市朝天区人民医院麻醉科,四川广元610000

出　　处：《实用医院临床杂志》2014年第4期221-223,共3页Practical Journal of Clinical Medicine

摘　　要：目的观察布托啡咯复合丙泊酚用于无痛胃镜检查的麻醉效果。方法选择ASAⅠ～Ⅱ级无痛胃镜检查患者120例,分成三组各40例。A组仅给予丙泊酚;B组先给予布托啡咯10μg/kg静脉注射,再静脉注射丙泊酚;C组先给予芬太尼0.5μg/kg静脉注射,再静脉注射丙泊酚。三组患者均按照丙泊酚1.5～2.5 mg/kg静脉注射,待患者入睡后再行胃镜检查,必要时追加丙泊酚。结果三组麻醉效果比较差异无统计学意义（P〉0.05）,B、C组VRS评分0分率高于A组,差异有统计学意义（P〈0.05）;麻醉后三组平均动脉压均明显降低（P〈0.05）,但组间差异无统计学意义（P〉0.05）;用药后C组心率明显减缓,与A、B组比较差异有统计学意义（P〈0.05）;B组呼吸抑制发生率低于C组,差异有统计学意义（P〈0.05）。结论丙泊酚复合布托啡咯或芬太尼用于无痛胃镜,麻醉效果优于单独使用丙泊酚。丙泊酚复合布托啡咯不良反应少,安全方便。Objective To observe the anesthesia effect of butorphanol combined with propofol in painless gastroscopy.Methods One hundred twenty ASA Ⅰ ～ Ⅱ grade patients,who were ready to accept painless gastroscopy,were randomly divided into three groups,40 in each group.The group A was only intravenously injected with propofol.The group B was first intravenously injected with1μg/kg of butorphanol and then propofol.The group C was first intravenously injected with 1μg/kg of fentanyl,and then propofol.The patients went to sleep before gastroscopy.If it was necessary,additional propofol will be re-injected. Results There was no significant difference in anesthesia effect among the three groups. VRS scores in the groups B and C were significantly higher than that in the group A（P 〈0. 05）. MAP was dramatically decreased in all the three groups（P 〈0. 05 ） but no significant difference was found among the groups. After injection of drugs, HR in the group C were significantly decreased when compared to other two groups（P 〈0. 05）. The in- cidence of respiratory inhibition in the group B was lower than that in the group C （ P 〈0. 05 ）. Conclusion Combination of propofol with butorphanol or fentanyl has better anesthesia effect than propofol alone in painless gastroscopic examination. Combination of propo- fol with butorphanol has fewer adverse reactions and it is safe and convenient.

关 键 词：丙泊酚 布托啡咯 胃镜 

分 类 号：R614.24[医药卫生—麻醉学]