2004-2012年ICU铜绿假单胞菌对抗菌药物敏感率的变化趋势  

Changing trend of drug susceptibility of Pseudomonas aeruginosa to antibiotics in ICU in 2004-2012

作　　者：郭宏玥[1] 鹿兴[2] 尚嘉鹏[3] 毛静怡[1] 张健东[4] 

机构地区：[1]天津市第三中心医院药剂科,天津300170 [2]天津市第三中心医院ICU,天津300170 [3]天津市药物研究院,天津300193 [4]天津市第三中心医院检验科,天津300170

出　　处：《中华医院感染学杂志》2014年第13期3196-3197,3200,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(81301985)

摘　　要：目的了解重症监护病房（ICU）中铜绿假单胞菌对常用抗菌药物的敏感率,为临床合理用药提供依据。方法对2004年1月-2012年12月ICU送检的痰液、血液、尿液、粪便、脓液等标本进行病原菌培养、鉴定和药敏试验,统计铜绿假单胞菌分离株数及对常用抗菌药物敏感率;采用WHONET 53软件进行统计分析。结果 ICU2004-2012年953株铜绿假单胞菌占7.3%～16.7%,且近两年有增多的趋势,各年度中铜绿假单胞菌对头孢哌酮/舒巴坦、亚胺培南保持较高敏感率,敏感率均〉50.0%,对其他抗菌药物出现不同程度的耐药。结论 ICU是铜绿假单胞菌感染的高发区,其耐药现象日趋严重,临床应根据药敏结果合理使用抗菌药物。OBJECTIVE To understand the susceptibility rate of Pseudornonas aeruginosa （P. aeruginosa） to com- monly used antibiotics so as to provide the basis for clinical rational drug use. METHODS Bacteria culture, identifi- cation and susceptibility testing were carried out on sputum, blood, urine, stool, pus and other specimens from patients in ICU of our hospital from Jan. 2004 to Dec. 2012, the number of isolation strains and sensitivity rates to commonly used antibiotics of P. aeruginosa were obtained by statistical analysis. RESULTS The constituent ra- tio of P. aeruginosa in ICU of our hospital from 2004 to 2012 was between 7.3% to 16.7%, and the strains of P. aeruginosa were increasing in the lagt two years. In each year, P. aeruginosa maintained a high sensitivity rate to cefoperazone/sulbactam, imipenem, the sensitivity rate was all 〉50%, and it showed resistance to other antimicrobial agents at different degrees. CONCLUSION ICU is a high incidence area for P. aeruginosa and the problem of its drug resistance is becoming more serious. The clinicians should use antibiotics reasonably based on the result of drug susceptibility testing.

关 键 词：重症监护病房 铜绿假单胞菌 抗菌药物 

分 类 号：R978.1[医药卫生—药品]