抗菌药物药珠植入术与闭合灌洗引流术治疗胫骨慢性骨髓炎疗效对比  

Comparative study on efficacies of antibiotic beads implantation and closure irrigation drainage in treatment of chronic osteomyelitis of tibia

作　　者：罗建军 顾峰 王家威 

机构地区：[1]焦作市武陟县第二人民医院骨科,河南焦作454950 [2]焦作市武陟县第二人民医院神经外科,河南焦作454950 [3]解放军第91中心医院精神科,河南焦作454150

出　　处：《中华医院感染学杂志》2014年第13期3208-3210,共3页Chinese Journal of Nosocomiology

基　　金：河南省医学科关基金资助项目(200584)

摘　　要：目的探究抗菌药物药珠植入术与闭合灌洗引流术治疗胫骨慢性骨髓炎疗效对比,以寻找更适合胫骨慢性骨髓炎的治疗方法。方法采用对比分析法将2010年1月-2011年1月进行治疗胫骨慢性骨髓炎的64例患者随机分等分为两组:对照组32例胫骨慢性骨髓炎患者采用闭合灌洗引流术进行治疗,试验组32例胫骨慢性骨髓炎患者采用抗菌药物药珠植入术进行治疗,对比两组患者的手术治疗次数、平均住院时间及治疗效果,所有数据应用SPSS 15.0软件进行分析。结果对照组治愈率为59.4%,细菌清除率为88.6%,平均住院时间(3.2±0.8)月,平均手术次数(3.0±1.9)次;试验组治愈率为87.5%,细菌清除率为93.0%,平均住院时间(2.1±1.2)个月,平均手术次数(2.5±1.1)次,两组患者的平均住院时间及总治愈率比较差异均有统计学意义(P<0.05)。结论抗菌药物药珠植入术的临床疗效比闭合灌洗引流术好,且患者的平均住院治疗时间短,值得临床广泛推广使用。OBJECTIVE To explore the efficacies of antibiotic beads implantation and closure irrigation drainage in the treatment of chronic osteomyelitis of tibia so as to find out a more suitable way to treat the chronic osteomyelitis. METHODS By means of the comparative analysis, totally 64 patients with chronic tibia osteomyelitis who were treated in the hospital from Jan 2010 to Jan 2011 were randomly divided into two groups, 32 patients in the control group were treated with closure irrigation drainage, while 32 patients in the experimental group were given the antibiotics beads implantation, then the times of surgical procedures, mean hospitalization duration, and therapeutic effect were compared between the two groups, and all the data were statistically analyzed with the use of SPSS 15.0 software. RESULTS The cure rate was 59.4% in the control group, 87. 5% in the experimental group; the bacterial clearance rate was 88.6% in the control group, 93.0% in the experimental group% the mean hospitaliza- tion duration was （3.2±0.8）months in the control group, （2.1±1.2）months in the experimental group; the av- erage times of surgical procedures was （3.0±l. 9） times in the control group, （2.5±1.1） times in the experimen- tal group; the differences in the mean hospitalization duration and the total cure rate between the two groups were significant（P〈0.05）. CONCLUSION The antibiotic beads implantation can achieve better clinical efficacy than the closure irrigation drainage, with the mean hospitalization duration shorter, and it is worthy to be widely promoted in the hospital.

关 键 词：抗菌药物药珠植入术 闭合灌洗引流术 胫骨 慢性胫骨骨髓炎 疗效 

分 类 号：R978.1[医药卫生—药品]