紫杉醇耐药基因、血小板反应蛋白及生存素在胃癌组织表达关系及其意义  

Correlation and significance of TXR1,survivin and TSP1 expression in the tissues of gastric cancer

作　　者：毕敬涛[1,2] 白志刚[2] 郭晏同[1] 赵景明[1] 张忠涛[2] 

机构地区：[1]北京积水潭医院普外科,北京100096 [2]首都医科大学附属北京友谊医院普外科,北京100050

出　　处：《中国实用外科杂志》2014年第7期649-653,共5页Chinese Journal of Practical Surgery

基　　金：国家自然科学基金项目(81172317)

摘　　要：目的探讨紫杉醇耐药基因(TXR1)、血小板反应蛋白(TSP1)以及生存素(survivin)在胃癌组织中的表达关系及其意义。方法收集2006年1月至2008年12月首都医科大学附属北京友谊医院经病理确诊的95例经根治性手术和规范化疗的Ⅱ、Ⅲ期胃癌病人临床资料及肿瘤标本,制作组织芯片,采用免疫组化检测TXR1、TSP1、survivin在胃癌组织的表达。结果入组胃癌病例中,3年无病生存组病例的TXR1、survivin表达阳性率明显低于复发转移组(P<0.05);与性别、年龄、有无淋巴结转移、细胞分化程度、肿瘤浸润深度、肿瘤分型无明显相关性。TXR1与survivin呈正相关,而与TSP1负相关。结论 TXR1和survivin的表达可作为判断胃癌预后的指标;TXR1、survivin、TSP1三者在胃癌中表达具有相关性,可能共同影响着胃癌的化疗疗效及预后。Objective To explore the value and correlation of taxol resistance gene 1（TXR1）, thrombospondin 1（TSP1） and survivin expression in the tissues of gastric cancer.Methods The clinical data and paraffin-embedded tumor samples with stagesⅡ and Ⅲ from 95 patients received Oxaliplatin-based chemotherapy were collected. The samples were made for tissue microarrays. The expression of TXR1,TSP1 and survivin in gastric tissue was analyzed by immunohistochemistry.Results In all gastric cancer cases, the expression level of TXR1 and survivin in group of 3-year disease-free survival was significant lower than that in group of recurrence or metastasis（P0.05）. There was no correlation between protein expression level and clincopathological parameters including age, sex, lymph node metastasis, lauren classification, cell differentiation, tumor infiltration and pTNM stage. The expression of TXR1 was positively related to that of survivin, while the expression of TSP1 showed converse pattern.Conclusion Expression of TXR1 and survivin can be regarded as the index for the prognosis of gastric cancer. There is certain correlation with the expressions of TXR1,survivin and TSP1, which may be affect the chemotherapic effect and prognosis of gastric cancer.

关 键 词：胃癌 紫杉醇耐药基因 生存素 血小板反应蛋白 

分 类 号：R6[医药卫生—外科学]