2型糖尿病患者幽门螺杆菌感染情况及其与颈动脉粥样硬化的关系研究  

Study on the relationship between the infection of helicobacter pylori and carotid atherosclerosis in patients with type2 diabetes

作　　者：刘剑雄[1] 张小强[1] 黄刚[1] 胡咏梅[1] 郑庆昆[1] 陈勇[1] 刘家勉[1] 

机构地区：[1]成都市第二人民医院心内科,610017

出　　处：《疑难病杂志》2014年第7期704-706,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的研究2型糖尿病(DM)患者幽门螺杆菌(HP)感染情况,探讨HiP感染与2型DM患者颈动脉粥样硬化的关系。方法以2型糖尿病患者281例为DM组,健康体检者86例为健康对照组,观察HP的感染率,并根据HP感染情况将DM分为感染亚组与末感染亚组,比较2个亚组血糖、血脂、颈动脉内膜中层厚度(IMT)、炎性因子,探讨HP感染与颈动脉粥样硬化的关系。结果 DM患者HP阳性率为85.4%(240/281).高于健康对照组的47.7%(41/86),差异有统计学意义(P<0.01);DM患者均存存血脂代谢异常,其中HP感染亚组较末感染亚组显著(P<0.05);健康对照组、未感染亚组及感染亚组IMT、CRP、IL-6及IL-8依次升高,IL-10依次降低(P均<0.05)。2型糖尿病患者IMT与CRP(r=0.62,P=0.016)、IL-6(r=0.57,P=0.022)及IL-8(r=0.64,P=0.007)均呈正相关,与IL-10呈负相关(r=-0.56,P=0.017)。结论 2型糖尿病患者对HP易感,HP持续感染与糖尿病颈动脉粥样硬化关系密切。Objective To investigate on type 2 diabetes mellilus（DM） patients with Helicobacter pylori（HP） infection,and to explore the relationship between HP infection and carotid atherosclerosis in patients with type 2 DM.Methods There were 281 patients with type 2 diabetic as DM group,86 cases of healthy people as healthy control group,observed the HP infection rate,and according to the situation of HP infection in DM patients,they were divided into infection subgroup and non-infection group,compared 2 groups of blood glucose,blood lipid,carotid artery intima media thickness（IMT）,inflammatory cytokines,and explored the relationship between HP infection and carotid atherosclerosis.Results DM patients＇ HP positive rate was 85.4%（240/281）,higher than 47.7%in the healthy control group（41/86）,the difference was statistically significant（P 〈0.01）;all of the DM patients have abnormal metabolism of lipid,HP infected sub group were more significant than in the uninfected group（P〈0.05）;the healthy control group,uninfected subgroup and infected subgroup＇s IMT,CRP,IL-6 and IL-8 increased respectively,IL-10 decreased（P 〈0.05）.IMT in patients with type 2 diabetes raellitus was positively correlated with CRP（r =0.62,P =0.016）,IL-6（r =0.57,P =0.022） and IL-8（r =0.64,P =0.007）,and negatively correlated with IL-10（r =-0.56,P =0.017）.Conclusion It demonstrated that the type 2 diabetic patients were susceptible to HP,HP persistent infection and carotid atherosclerosis is closely related.

关 键 词：糖尿病 2型 幽门螺杆菌 颈动脉内膜中层厚度 炎性因子 

分 类 号：R587.1[医药卫生—内分泌]