环磷腺苷葡氨治疗老年慢性收缩性心力衰竭的疗效研究  

Effect of Meglumine Adenosine Cyclophosphate on Aged Patients with Chronic Systolic Heart Failure

作　　者：邵凌云[1,2] 吴明[1] 刘表虎[3] 王安才[1] 

机构地区：[1]皖南医学院弋矶山医院老年医学科,安徽省芜湖市241000 [2]芜湖市鸠江区医院普内科 [3]皖南医学院弋矶山医院超声医学科,安徽省芜湖市241000

出　　处：《实用心脑肺血管病杂志》2014年第7期27-29,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察环磷腺苷葡胺(MAC)治疗老年慢性收缩性心力衰竭(CHF)的临床疗效及安全性。方法选择2011年9月—2013年9月我院住院治疗的老年CHF患者76例,将其随机分为常规治疗组37例和MAC组39例。两组均给予常规抗心力衰竭治疗,在此基础上MAC组患者给予MAC进行治疗,均以14 d为1个疗程。比较两组疗效、治疗前后心功能指标〔包括左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)及左心室射血分数(LVEF)〕和B型利钠肽(BNP)水平变化情况,并记录药物不良反应。结果 MAC组患者治疗总有效率为94.9%(37/39),高于常规治疗组的70.2%(26/37)(P<0.05)。治疗前两组患者LVEDV、LVESV、LVEF和BNP比较,差异均无统计学意义(P>0.05)。治疗后MAC组患者LVEF高于常规治疗组,BNP水平低于常规治疗组(P<0.05);两组患者LVEDV和LVESV比较,差异均无统计学意义(P>0.05)。治疗期间MAC组患者未发生严重不良反应。结论MAC治疗老年CHF疗效显著,能有效增强心肌收缩力,减轻心力衰竭症状且安全性好。Objective To study the effect of meglumine adenosine cyclophate（MAC）on aged patients with chronic systolic heart failure. Methods 76 aged patients with chronic systolic heart failure admitted to this hospital from Septmber 2011 to September 2013 were randomly divided into control group（n = 37）and MAC group（n = 39）. Both groups given convention-al therapy,while the MAC group received extraly MAC. Both groups treated for 14 days. The clinical effect,heart function （LVEDV,LVESV,LVEF）and BNP level before and after treatment,and adverse reactions were recorded. Results After treatment,the total effective rate of MAC group was 94. 9% （37 / 39）,was significantly higher than that of control group of 70. 2% （26 / 37）（P 〈 0. 05）. Before treatment,there was no significant differences in LVEDV,LVESV,LVEF and BNP level between the two groups;afte treatment,LVEF was higher,BNP level was lower in MAC group than those of control group （P 〈 0. 05）,but there was no significant differences in LVEDV,LVESV between the two groups. No one occurred severe ad-verse reactions in MAC group during treatment. Conclusion MAC has a certain clinical effect on aged patients with chronic sys-tolic heart failure,it can improve myocardial contractility and mitigate the symptoms,with good safety.

关 键 词：环磷腺苷葡胺 老年人 心力衰竭 收缩性 治疗结果 

分 类 号：R541.6[医药卫生—心血管疾病]