急性心理应激下血小板活化参数的变化及其机制探讨  

Analysis of Acute Psychological Stress induced the Changes of Platelet Indices and its Mechanisms

作　　者：崔益芬[1] 邓玉琴[1] 白鹰[2] 范亚欣[3] 丁晓倩[1] 唐一源[1] 

机构地区：[1]大连理工大学神经信息学研究所,辽宁大连116024 [2]大连医科大学附属第一医院神经内科,辽宁大连116021 [3]大连市血液中心,辽宁大连116001

出　　处：《现代生物医学进展》2014年第22期4269-4272,共4页Progress in Modern Biomedicine

基　　金：国家重点基础研究发展计划(973计划)课题(2012CB518200)

摘　　要：目的:探讨急性心理应激下健康人群血小板活化参数的变化及其与性别、年龄的相关性,并分析其可能的机制。方法:检测54名健康被试者急性心理应激前后的血小板四项变化,包括血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)和大血小板比率(P-LCR)。随后,将被试者分成男、女性组或中、老年组,对其血小板四项结果进行组内及组间比较。结果:急性心理应激可导致健康人群中MPV、PDW和P-LCR的显著增加(P<0.05),但年龄分组或性别分组组间均未见显著差异(P>0.05)。结论:实验性急性心理应激可导致健康人群血小板活化指标MPV、PDW和P-LCR的显著增加,但与年龄和性别无关。Objective：To investigate the changes of platelet activation parameters under acute psychological stress and its correlation with age and gender, and analyze its possible mechanisms, female and male groups. The aim was to determine whether an acute laboratory psychological stress task produced platelet reactivity by using three haematologicaly markers： MPV, PDW and P-LCR in healthy participants and whether there is age or gender related differences. Methods： Fifty-four healthy volunteers were performed a psychological stress challenge. The blood samples were obtained and the blood platelet count（PLT）, mean platelet volume（MPV）,platelet distribution width（PDW） and platelet-large cell ratio（P-LCR） were detected and compared pre-stress and immediately post-stress prior to haematologyical analysis. Then these parameters were compared between middle-aged and elderly participants, or male and female participants. Results： The acute psychological stressor induced significant increase of MPV, PDW and P-LCR in healthy participants（P〈0.05）, but there was no significant difference between middle aged and elderly participants, or male and female participants（P0〈.05）. Conclusion： MPV, PDW and P-LCR were sensitively increased after acute lab psychological stress in healthy adults, which may had no correlation with the age and gender.

关 键 词：急性心理应激 血小板活化 血小板平均体积 血小板分布宽度 大血小板比率 

分 类 号：B849[哲学宗教—应用心理学] R331[哲学宗教—心理学]