原发性高血压患者尿微量白蛋白和冠状动脉狭窄性病变程度的关系  

The Relationship between Microalbuminuria and Primary Stenotic Coronary Lesions in Patients with Hypertension

作　　者：赵静[1] 魏淑岩 李然[1] 马光[1] 索普霞 

机构地区：[1]河北省保定市第二中心医院心内1科,河北保定072750

出　　处：《现代生物医学进展》2014年第23期4497-4500,共4页Progress in Modern Biomedicine

摘　　要：目的:分析并探讨原发性高血压患者尿微量白蛋白和冠状动脉狭窄性病变程度的关系。方法:选择2010年8月至2013年8月符合条件的患者按照MAU阳性与否分为阳性组和阴性组各98例,分别记录并比较尿微量白蛋白、冠状动脉造影情况及Gensini积分。结果:1阳性组与阴性组患者在性别、年龄、病程、吸烟史、饮酒史、高血脂症史、血肌酐水平比较差异无统计学意义(P>0.05)。2两组患者收缩压、舒张压、脉压及脉压指数比较,差异无统计学意义(P>0.05)。3阳性组相比阴性组冠状动脉造影阳性率高,双支及三支冠脉病变率亦高,差异有统计学意义(P<0.05);且阳性组Gensini积分显著高于阴性组(P<0.05)。结论:原发性高血压伴有MAU阳性患者存在相对更严重的冠状动脉狭窄性病变,通过检测MAU指标有助于及时判断患者病情并指导治疗方案。Objective： To analyze and investigate the relationship between mieroalbuminuria and primary stenotic coronary lesions in patients with hypertension. Methods： We chose eligible patients from August 2010 to August 2013 and divided them into MAU positive and negative group with 98 cases in each group. We recorded and compared the urinary albumin, coronary angiography and Gensini scores of the two groups. Results： ① There was no significant difference between positive group and negative group in the gender, age, disease duration, smoking history, drinking history, history of hyperlipidemia, serum creatinine level （P〉 0.05）. ② There was no significant difference between two groups in the systolic blood pressure, diastolic blood pressure, pulse pressure and pulse pressure index （P〉0.05）. ③Compared with the negative group, the positive group＇s positive rates of coronary angiography, and three double vessel coronary artery disease rates were higher and the difference was statistically significant （P 〈0.05）. Gensini scores of positive group was significantly higher than that of the negative group （P〈0.05）. Conclusion： There is a more severe coronary artery stenosis on essential hypertension accompanied MAU, and timely detection MAU indicators can help determine the patient＇s condition and instruct the treatment.

关 键 词：原发性高血压 尿微量白蛋白 冠状动脉狭窄 

分 类 号：R544.1[医药卫生—心血管疾病]