丹红注射液治疗稳定型心绞痛的系统评价  

Systemic Review of Danhong Injection for Treatment of Stable Angina Pectoris

作　　者：吴嘉瑞[1] 张晓朦[1] 张冰[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《中国实验方剂学杂志》2014年第14期219-223,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划项目(2006BAI21B11);北京中医药大学科研创新团队项目(2011-CXTD-14)

摘　　要：目的:系统评价丹红注射液治疗稳定型心绞痛的疗效及安全性。方法:全面系统地收集丹红注射液治疗稳定型心绞痛的随机对照试验,采用Cochrane风险评价表评价研究质量,提取资料并通过RevMan5.2进行Meta分析。结果:共纳入9篇文献,共计受试者596例。其中1篇按照入院先后顺序分组,1篇提及双盲,其他均只提及随机未说明盲法。Meta分析的结果显示,丹红注射液联合西医常规疗法治疗稳定性心绞痛具有较好的疗效,可以有效提高总有效率[RR=1.30,95%CI(1.21,1.41),P<0.000 01],减少心绞痛发作频率,改善血流变指数。有5篇文献表示未发生不良反应,2篇研究报道了共6例不良反应,无重大不良反应发生。结论:丹红注射液用于治疗稳定型心绞痛具有一定的疗效和安全性。Objective： To evaluate systematically the clinical efficacy and safety of Danhong injection for the treatment of stable angina pectoris. Method： Randomized controlled trials （RCTs） about Danhong injection for stable angina pectoris were searched systemically and comprehensively. Two reviewers assessed the quality of the included studies by the Cochrane risk of bias, and extracted the information. Meta-analysis was conducted with the software Review Manager 5.2. Result： A total of 9 studies with 596 participants were included, an（] the quality of the studies was relatively low. There was one study divided into groups by the order of seeking medical advice, one study used the double-blinding method, one study may have 2 patients dropped, and the others mentioned random only. In the recta-analysis, the results of Danhong group were significantly superior to the west conventional therapy group in increasing the total effective rate [RR = 1.30, 95% CI （1.21, 1.41）, P 〈0.000 01 ], reducing the frequency of angina pectoris, and improving the herorheology index. There were 5 authors explained none adverse drug reactions （ADR） reported in their studies, and 2 studies reported 6 cases of ADRs, none series ADR occurrence. Conclusion： Comparing with the conventional therapy of the control group used fi）r treating stable angina pectoris, Danhong injection combined with the conventional therapy was relatively effective and safety, which was based on the systematic review.

关 键 词：丹红注射液 稳定型心绞痛 系统评价 META分析 随机对照试验 

分 类 号：R287[医药卫生—中药学]