洛芬待因镇痛作用的组方分析  

Analyses of the complex prescriptions of Luofendeine

作　　者：方治平[1] 刘小康[1] 肖逸[1] 宋晓红[1] 李玉红 

机构地区：[1]华西医科大学药理教研室,成都610041 [2]皖南医学院药物研究所,芜湖241001

出　　处：《中国临床药理学与治疗学》2000年第1期54-58,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的观察洛芬待因(可待因 +布洛芬)的镇痛作用及其组方分析。方法采用小鼠扭体法、热板法、二甲苯所致小鼠耳廓肿胀法等毒理和药效试验 ,观察洛芬待因及其各组分的镇痛作用 ,用金氏法分析药物相互作用性质。结果可待因和布洛芬按13∶200配方其镇痛作用增强 ,同时也能增加布洛芬的抗炎作用 ,毒性下降。Aim To study the actions of Luofendeine and its component. Methods LD50 tests of Luofendeine and its component, heat_board text and body_twisting test of mice were pertormed to learn its analgesic and antiinflammatory actions. Results The analgesic action and antiinflammatory action were increased when codamine was mixed with buluofen by the rate of 13∶200,without increasing its toxicity. Conclution The complex prescription of Luofendeine is rational and can increase the analgesic action obviously.

关 键 词：洛芬待因 镇痛 抗炎 药物相互作用 

分 类 号：R971.1[医药卫生—药品] R441.1[医药卫生—药学]